Lichenoid drug eruption induced by rosuvastatin, a case report and review literatures (Eng)

Article Sidebar

PDF
เผยแพร่แล้ว: ก.ย. 5, 2025

Main Article Content

Angkana Norasetthada
Department of Internal medicine, rheumatology unit, Buddhachinaraj Phitsanulok Hospital, Thailand.

บทคัดย่อ

Cutaneous drug reactions have a wide variety of clinical features. Lichenoid drug eruptions (LDE) are rare and it may be difficult to differentiate them from idiopathic lichen planus. Gold, quinine, quinidine and penicillamine are well-known inducers of such eruptions1,2, but there are only a few reports of lichenoid eruption induced by 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statin)2,3. I described a lichenoid eruption linked to atorvastatin and rosuvastatin. His clinical features, in addition to histological findings, helped to establish the diagnosis. The cutaneous eruption resolved one month after the cessation of rosuvastatin. and a proposed alternative regimen to reduce total cholesterol (TC) and LDL-C in a patient with atherosclerotic heart disease.
For this case study, the patient gave written informed consent.

Article Details

รูปแบบการอ้างอิง
1.
Norasetthada A. Lichenoid drug eruption induced by rosuvastatin, a case report and review literatures (Eng). Thai J Rheu [อินเทอร์เน็ต]. 5 กันยายน 2025 [อ้างถึง 13 กันยายน 2025];2(3):36-42. available at: https://he04.tci-thaijo.org/index.php/tjr/article/view/3595
ฉบับ
ปีที่ 2 ฉบับที่ 3 (2025): วารสารโรคข้อและรูมาติสซั่ม
ประเภทบทความ
รายงานผู้ป่วย
Creative Commons License

อนุญาตภายใต้เงื่อนไข Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

(ใส่ข้อความเดียวกันกับ ก๊อปปี้ไลน์ก็ได้)ดูตัวอย่างได้ที่หน้าบทความ---บทความนี้ตีพิมพ์เป็นลิขสิทธื์ของใคร...

เอกสารอ้างอิง

Halevy S, Shai A. Lichenoid drug eruptions. J Am Acad Dermatol 1993; 29: 249 – 255.

Keough GC, Richardson TT, Grabski WJ. Pravastatin induced lichenoid drug eruption. Cutis 2000; 61: 98-100.

Roger D, Rolle F, Labrousse F, Brosetti A, Bonnetblanc JM. Simvastatin-induced lichenoid drug eruption. Clin Exp Dermatol 1994; 19: 88 – 89.

Ellgehausen P, Elsner P, Burg G. Drug-induced lichen planus. Clin.Dermatol. 1998;16(3):325-32.

Thompson DF, Skaehill PA. Drug-induced lichen planus. Pharmacotherapy 1994;14(5):561-71.

Emanuel P, Oakley A. Lichenoid drug eruption. Clues to diagnosis in dermatopathology. Derm101.com (accessed 10 September 2018). https://dermnetnz.org/topics/lichenoid-drug-reaction-pathology

Mullins RJ, Lones R, Dutta B. Lichenoid drug eruption secondary to topical timolol and dorzolamide eye-drops. Australas J Dermatol 2004; 45:151-2.

Ellgehausen P, Elsner P, Burg G. Drug-induced lichen planus. Clin.Dermatol. 1998;16(3):325-32.

Thompson DF, Skaehill PA. Drug-induced lichen planus. Pharmacotherapy 1994;14(5):561-71.

Jain S.Dermatology Illustrated study guide and comprehensive board review.2nd ed.Springer; Switzerland: 2017. pp.106–109.

Dutch SmPC Lescol®. (version date: 1-11-2013, access date: 3-4-2014).

http://db.cbgmeb.nl/IB-teksten/h18719.pdf.

Dutch SmPC Zocor®. (version date: 31-12-2013, access date: 3-4-2014)

http://db.cbgmeb.nl/IB-teksten/h13193.pdf.

Dutch SmPC Lipitor®. (version date: 2-1-2014, access date: 3-4-2014).

http://db.cbgmeb.nl/IB-teksten/h21081.pdf.

Dutch SmPC Selektine®. (version date: 30-4-2013, access date: 3-4-2014).

http://db.cbg-meb.nl/IB-teksten/h13755.pdf.

Dutch SmPC Crestor®. (version date: 23-12-2013, access date: 3-4-2014).

http://db.cbg-meb.nl/IB-teksten/h26872.pdf.

Dutch SmPC Vezepra®. (version date: 19-8-2012, access date: 22-4-2014).

http://db.cbg-meb.nl/IB-teksten/h103422.pdf.

Dutch SmPC Livazo®. (version date: 19-8-2012, access date: 22-4-2014).

http://db.cbgmeb.nl/IB-teksten/h103768.pdf.

Roger D, Rolle F, Labrousse F, Brosset A, Bonnetblanc JM. Simvastatin-induced lichenoid drug eruption. Clin.Exp.Dermatol. 1994;19(1):88-9.

Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L. Simvastatin induced lichen planus pemphigoides. Ann.Dermatol.Venereol. 2003;130(2 Pt 1):187-90.

Keough GC, Richardson TT, Grabski WJ. Pravastatin-induced lichenoid drug eruption. Cutis 1998;61(2):98-100.

Pua VS, Scolyer RA, Barnetson RS. Pravastatin-induced lichenoid drug eruption. Australas.J.Dermatol. 2006;47(1):57-9.

Forouzan P, Riahi RR, Cohen PR. Atorvastatin-induced Lichenoid Drug Eruption: A Case Report and Review of Statin-associated Cutaneous Adverse Events Cureus 12(3): e7155.

https://doi.org/10.7759%2Fcureus.7155

Vesza Z, Pires C, Pedro Marques da Silva. Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment.

https://doi.org/10.12890%2F2018_000844.

Wong ITY, Huang Y, Zhou Y. Drug Eruption to Rosuvastatin With Recurrence on Simvastatin: A Case Report. Journal of cutaneous medicine and surgery.Volume 22, Issue 3:359-361.

https://doi.org/10.1177/1203475418756376

Sebok B, Toth M, Anga B, Harangi F, Schneider I. Lichenoid drug eruption with HMGCoA reductase inhibitors (fluvastatin and lovastatin). Acta Derm.Venereol. 2004;84(3):229-30.

Lakshmi C,Srinivas C R, Ramachandran B, Pillai SB, Nirmala V.Perforating lichenoid reaction to amlodipine.. Indian J Dermatol. 2008; 53(2): 98–99.

How OJ, Muhamad R, Muthusamy R, Rahman FA, Zulkifl MM, Amlodipine-induced lichenoid drug eruption: A case report. Bangladesh Journal of Medical Science. 2023; 22(1): 229-233.

Guijarro BG, Sánchez L. Lichenoid reaction caused by Clopidogrel, a new anti-platelet drug. Med Oral. 2003;8(1):33-7.

Upadhayai JB, Nangia AK, Mukhija RD, et al. Cutaneous reactions due to antihypertensive drugs. Indian J Dermatol 2006; 51: 189-91

Mullins RJ, Lones R, Dutta B. Lichenoid drug eruption secondary to topical timolol and dorzolamide eye-drops. Australas J Dermatol 2004; 45: 151-2

Bodmer M, Egger SS, Hohenstein E, et al. Lichenoid eruption associated with the use of nebivolol. Ann Pharmacother 2006; 40 (9): 1688-9

Gange RW, Jones EW. Bullous lichen planus caused by labetalol. BMJ 1978;1 (6116): 816-7.

Beckman KA, Chanes L, Kaufman SR. Lichen planus associated with topical beta-blocker therapy. Am J Ophthalmol 1995; 4: 530-1.

O’Brien TJ, Lyall IG, Reid SS. Lichenoid eruption induced by sotalol. Australas J Dermatol 1994; 35: 93-4.

Firth AN, Reade CP. Angiotensin-converting enzyme inhibitors implicated in oral mucosal lichenoid reactions. Oral Surg Oral Med Oral Pathol. 1989; 67: 41-44.

Vollenweider SR, Mainetti C, Donath R, Saurat JH. Enalapril-induced lichen planus-like eruption. J Am Acad Dermatol. 1995; 32 (2): 293-295.

Ruiz VR, Blasco MJ, Linares SJ, Serrano OS. Lichen planus-like eruption due to enalapril. JEADV. 2003; 17: 601-619.

Barrios V, Escobar C, Cicero AF, Burke D, Fasching P, Banach M, Bruckert E. A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: review of the clinical evidence. Atheroscler Suppl. 2017;24:1–15.