Epidemiological Distribution of High Risk Human Papillomavirus Genotype and Associated Factors of HPV Infection with Cervical cancer in The Female aged 30-60 Years at Roi-ET Province

Abstract

Cervical cancer is the second most common cancer affecting Thai women. Human papilloma virus (HPV) is the most viral sexually transmitted infection of the reproductive tract, and cervical cancer is the most common HPV-related disease. Therefore, the objective of this study was to determine the prevalence of HPV infection and risk factors associated with infection among women attending the cervical cancer screening. This was a cross-sectional study from Roi-Et hospital were selected and 377 women aged 30-60 years old were invited to participate in cervical cancer screening by both cytology and HPV testing. Sociodemographic data were collected using a self-administered questionnaire. Multivariate analyses were performed to assess the factors associated with HPV infection at p-value 0.05.

The result found that HPV genotype were classified as low risk (LR) and high risk (HR) by nucleotide sequencing. In total, 59.7 (225/377) of the participants had HPV-DNA, and HR-HPV was the most prevalent type 16,18 (34.8%), LR-HPV 29.8% respectively. Furthermore, age at first sexual, number of sexual partners, history of contraception, and history of alcohol consumption were statistically significantly associated with HPV infection (p-value < 0.05). Conclusion: The prevalent of HPV was high in married women, and especially in women who had normal cytology result, which suggests the need for greater screening for HPV infection in women’s primary health care.