Outcome Of Therapeutic Hypothermia in Perinatal Hypoxic-ischemic Encephalopathy Infant in Khon Kaen Hospital
Keywords:
Neonates, Hypoxic-ischemic encephalopathy, Therapeutic Hypothermia, DevelopmentAbstract
Background : Hypoxic-ischemic encephalopathy (HIE) in Newborn is one of the neonatal emergencies requiring the immediate treatment. Nowadays, There is treatment by Therapeutic Hypothermia (TH) help to improve the outcomes for HIE.
Objective : To identify the outcomes and risk factors of TH in Perinatal HIE infant in KhonKaen Hospital.
Methods : A descriptive study was investigated in the neonatal intensive care unit at KhonKaen Hospital, Thailand from October 2018 to September 2020.
Results : A total number of 30 neonates with HIE were identified with a female than male. There were Moderate HIE 15 and Severe HIE 15. The most common neonate born in KhonKaen Hospital 17 (56.7%). There were group 1 survived and normal development neonates 13 (43.3%), group 2 survived and global delay development neonates 4 (13.4%) and group 3 dead neonates 13 (43.3%). However, The different of mode ventilator (P-value 0.007), albumin < 2.5 mg/dL (P-value 0.010) and intraventricular hemorrhage (P-value 0.005) were in three groups neonates with statistical significance.
Conclusion : Moderate or severe HIE neonates had treatment by TH higher survival rate but some neonates had abnormal development. The different of mode ventilator, albumin and intraventricular hemorrhage were affecting treatment in three groups neonates.
Downloads
References
ฉัตรฉาย เปรมพันธ์พงษ์. Hypoxic-ischemic encephalopathy. ใน: สันติ ปุณณะหิตานนท์, บรรณาธิการ. Practical Approaches For Neonatal Problems. กรุงเทพ: บริษัท แอคทีฟ พริ้นท์ จำกัด, 2558: 48-59.
Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischemic encephalopathy. Early
Hum Dev. 2010; 86: 329-38.
Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976; 33: 696-705.
Finer NN, Robertson CM, Richards RT, Pinnell LE, Peters KL. Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome. J Pediatr. 1981; 98:112-7.
Robertson C, Finer N. Term infants with hypoxic-ischemic encephalopathy: outcome at 3.5 years. Dev Med child Neurol. 1985;27: 473-84.
Levene MI, Sands C, Grindulis H, Moore JR. Comparison of two methods of predicting outcome in perinatal asphyxia. Lancet. 1986;1: 67-9.
Glenys Dixon, Nadia Badawi, Jennifer J. Kurinczuk, John M. Keogh, et al. Early developmental Outcomes After Newborn Encephalopathy. Pediatrics 2002; 109:26-33.
Shankaran, S., et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic ischemic encephalopathy. Pediatrics. 2008; 122 (4):791-8.
Gluckman PD, Wyatt JS, Azzopardi DV, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy:
multicenter randomized trial. Lancet . 2005;365: 663-70.
Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischemic encephalopathy. Cochrane Database Syst Rev. 2013; 1: CD003311
Papile, L. A., et al. Hypothermia and neonatal encephalopathy. Pediatric. 2014; 133(6):
-50.
วณิชยา วันไชยธนวงศ์. ลักษณะทางคลินิกที่เพิ่มความเสี่ยงต่อพัฒนาการล่าช้า ในเด็กทารกที่ขาดออกซิเจนอย่างรุนแรงระหว่างคลอด. วารสารกุมารเวชศาสตร์ ฉบับเดือนกรกฎาคม-กันยายน 2560: 185-94.
Laptook A, Tyson J, Shankaran S, et al. Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. Pediatrics. 2008; 122(3): 491-9.
Gyrukovits Z, Maro′tiA′, Re′nes L, Ne′meth G, Pa′l A, Orvos H. Adrenal haemorrhage interm neonates: a retrospective study from the
period 2001-2013. J Matern Fetal Neonatal Med. 2015; 28(17): 2062-5.
Montasser N, Deirdre M, Geraldine B. et al. Early blood glucose profile and neurodevelopmental outcome at two years in
neonatal hypoxic-ischemic encephalopathy. BMC Pediatrics 2011, 11: 10
Prabhavathi R, Sandhya. V, Govindaraj M, Dr. Puttaswamy. M. Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns- a case control study. Pediatric Review. 2018 Feb; 5(2): 55-9.
ชัชชญา ปุณญาภัสส์, แสงแข ชำนาญวนกิจ, ปริศนา พานิชกุล, ธานินทร์ พิรุณเนตร. การศึกษาเปรียบเทียบผลการประเมินระบบประสาทระหว่างทารกกลุ่ม
เสี่ยงที่มีผลการตรวจวิเคราะห์แก๊สในหลอดเลือดแดงสายสะดือผิดปกติและทารกที่มีผลการตรวจปกติ. วารสารกรมการแพทย์ ปีที่ 44 ฉบับที่ 2 มีนาคม-เมษายน 2565: 90-95.
Ross MG. Abstract for Reference 60 of “Umbilical cord acid-base analysis at delivery”. Am J Obstet Gynecol. Epub 2018 Dec 6. 2019;220(4):348.
Sabir H, Jary S, Tooley J, Liu X, Thoresen M. Increased inspired oxygen in the first hours of life ia associated with adverse outcome in
newborns treated for perinatal asphyxia with therapeutic hypothermia. J Pediatr. 2012;161(3): 409-16.
Akram E, Naglaa F, Hany A. et al. Hepatic Injury in Neonates with Perinatal Asphyxia. Global Pediatric Health Volume8: 1-9.
Groenendaal F, van Bel F (Jun12,2019) Perinatal asphyxia in term and late preterm infants. Retrieved from:https://www.uptodate.com/contents/perinatal-asphyxia-in-term-and-late-preterm-infants.
Thyagarajan B, Tillqvist E, Baral V, Hallberg B, Vollmer B, Blennow M. Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischemic encephalopathy is safe and feasible. Acta Paediatr.2015; 104(2): 146-51.
Deepak C. Biomarkers for Prognostication in Hypoxic-Ischemic Encephalopathy. The Indian Journal of Pediatrics (October 2020) 87(10): 777-8.
American Academy of Pediatrics. Committee on Fetus and Newborn. Use of inhaled nitric oxide. Pediatrics.2000; 106(2Pt1): 344-5.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
