Treatment outcome of acute lymphoblastic leukemia in children in Chiangrai Prachanukroh hospital

Abstract

Background : Acute lymphoblastic leukemia (ALL) has the most incidence in pediatricnmalignancy 60 – 75 % which Chiangrai Prachanukroh hospital has been using Thai Pediatricn Oncology Group National protocol (ThaiPOG) for treatment.
Objective : to study survival years of pediatric ALL using ThaiPOG protocol at Chiangrai Prachanukroh hospital from January 1,2013 to January 1 ,2019 including remission and relapsed rate also complications after treatment by using ThaiPOG protocol 2008 onward.
Method : A Descriptive study of pediatric ALL which using ThaiPOG protocol at Chiangrai Prachanukroh hospital from January 1,2013 to January 1 ,2019.
Result : 1st year survival ,3rd year survival and 5th year survival was 92.30% , 83.33% and 66.67% respectively. Remission rate in Standard risk group 90.91% High risk group 81.82% and Very high risk group 100 %.Relapsed rate in Standard risk group 13.64% High risk group 81.82% and none in Very high risk group. The most common complication was febrile neutropenia
Conclusion : Treatment of ALL in Chiangrai Prachanukroh hospital used Thai POG protocol found that there was slightly higher survival rate in first few years but 5th year survival and relapsed rate was not different compare with other hospital in Thailand. In order to improve outcome, there should have hospital guideline in management febrile neutropenia which is the most common complication in pediatric ALL including continuous monitor outcome of treatment