Comparison of outcome between INSURE method and conventional mechanical ventilation method after surfactant administration in preterms with respiratory distress syndrome
Keywords:
Respiratory distress syndrome, INSURE, Conventional mechanical ventilation, surfactantAbstract
Background : The INSURE method (Intubation-SURfactant-Extubation) is increasinglybeing used to treat the respiratory distress syndrome in preterm infants and associated with declining the necessity for mechanical ventilation and reducing it is associated adverse events.
Objectives : To evaluate the effectiveness of surfactant therapy using conventional methods for treatment of RDS are compared with surfactant administration, use of mechanical ventilation for a brief period and NCPAP (Nasal Continuous Positive Airway Pressure) (INSURE method)
Methods : A retrospective study was performed, including preterm newborn infants with diagnosed RDS, who were admitted in NICU of Udonthani Hospital between 1st september 2017 and 31th January 2021. The patients were devided into two CMV (conventional mechanical ventilation) and INSURE groups.
Results : The total number of neonates enrolled in this study was ninety. The mean gestational age and birth weight were 29±3 weeks and 1,253±473 grams respectively. INSURE method was successful in 19 among 23 (82.6%). The duration of mechanical ventilation, oxygen therapy, and incidence of BPD, VAP, IVH were significantly decreased in INSURE group in comparison to CMV group.
Conclusion : INSURE method is very effective method in the management of respiratory distress syndrome. It is associated with decrease the need for mechanical ventilation, oxygen therapy and decline in the neonatal mortality rate.Thus, it seems rational to perform this method as the initial treatment for neonates with moderate to severe RDS.
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