the The incidence rate and risk factors of healthcare-associated infections in the neonatal care unit at a tertiary care hospital in northern Thailand
Keywords:
healthcare associated infections (HAI), neonatal intensive care unit, risk factor, mortality in neonate, bloodstream infectionAbstract
Background: Healthcare-associated infection (HAI) is a common complication in neonatal intensive care unit (NICU) which is the important cause of mortality and morbidity in neonates.
Objective: To investigate the incidence rate of HAI, risk factor associated to HAI and the bacteriological profile of micro-organisms affecting infection in NICU.
Method: A 1-year prospective cohort study collecting data in neonates admitted in NICU between August 20, 2023 and August 20, 2024.
Results: Total population in this study were 624 neonates founded HAI 107 episodes, the incidence rate of HAI was 17.2%. Risk factors associated with HAI were birth asphyxia (Apgar score at 5 min less than 7) (aHR 2.44, p value 0.03), umbilical venous catheter (UVC) insertion longer than 7 days (aHR 1.88, p value 0.04) and longer length of stay (aHR 0.97, p value 0.02). Common types of infection were primary bloodstream infection (35.5%), ventilator-associated pneumonia (22.4%) and central line-associated bloodstream infection (17.8%). Organism was not detected 55.1%. The three most common pathogens detected were Acinetobacter baumannii (24.3%), coagulase-negative staphylococcus (7.5%) and Escherichia coli (3.1%), respectively.
Conclusion: The incidence rate of HAI in neonates admitted in NICU was 17.2%.
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