Risk factors of severe sepsis in pediatric patients with febrile neutropenia in Lampang Hospital
Keywords:
ภาวะไข้ร่วมกับเม็ดเลือดขาวนิวโทรฟิลต่ำ, การติดเชื้อในกระแสเลือดรุนแรง, ปัจจัยเสี่ยงAbstract
Background: Febrile neutropenia is a common issue in pediatric patients receiving chemotherapy. High risk patients are more susceptible to severe disease with high morbidity and mortality rates. Identifying the risk factors of severe sepsis in pediatric patients with febrile neutropenia can help in making treatment decisions.
Objectives: Study the risk factors associated with severe sepsis in pediatric patients with febrile neutropenia in Lampang hospital.
Methods: A retrospective study was conducted between January 1, 2015 and May 31, 2024. Patients between 0-15 years old were enrolled through review of medical records and divided into severe sepsis and non-severe sepsis group. Sample size calculation was based on a pilot study by comparing two population proportion method.
Results: There were 197 episodes of febrile neutropenia, 116 (58.8%) were female. The average ages were 11 years. There were 32 episodes in the severe sepsis group. The significant risk factors included female (OR 3.62, 95%CI 1.40, 9.37), temperature ≥ 40OC (OR 15.04, 95%CI 1.43, 158.02) and abnormal CT scan (OR 5.49, 95%CI 1.38, 21.74).
Conclusion: Timely monitoring and treatment are crucial in pediatric cancer patients, particularly in females, those presenting with a body temperature of 40 °C or higher, and those with abnormal CT findings, to prevent complications and reduce mortality rates.
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