Outcome of Childhood Acute Lymphoblastic Leukemia treated using the Thai National Protocols : ThaiPOG 2006 and ThaiPOG 2014 at Maharat Nakhon Ratchasima Hospital
Keywords:
Acute lymphoblastic leukemia, outcome, survivalAbstract
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Standard National protocol by Thai Pediatric Oncology Group (ThaiPOG) was used since 2006.
Objective: To evaluate the outcome of treatment childhood ALL at Maharat Nakhon Ratchasima Hospital (MNRH) using the national protocols 2 consecutive periods.
Methods: The retrospective study of newly diagnosed with ALL, who were treated at MNRH 2 consecutive period. First period is between 1 January 2010 – 31 August 2014 treated with ThaiPOG 2006 protocol. Second period between 1 September 2014- 31 December 2018 treated with ThaiPOG 2014 protocol. Overall survival (OS) and event-free survival (EFS) were determined by using Kaplan-Meier survival curves.
Results: Two hundred and sixty-five patients were enrolled in this study, with predominantly in male (male: female =1.5:1), age 1-5 year (44.5%) and pre B-cell (63.4%). There were 130 patients in 1st period and 135 patients in 2nd period. The 5-year OS rate of total patients, ThaiPOG 2006, ThaiPOG 2014 were 68.0%, 66.4% and 70.3% respectively. The 5-year EFS rate of total patients, ThaiPOG 2006, ThaiPOG 2014 were 73.4%, 68.2% and 79.9% respectively. Relapse rate of total patients, ThaiPOG 2006, ThaiPOG 2014 were 22.3% ,29.2% and 15.6% respectively (p=0.008).
Conclusion: Outcome of treatment of childhood ALL at Maharat Nakhon Ratchasima Hospital is good. The study shows that ThaiPOG 2014 protocol tends to improve overall survival rates, event free survival rates and decrease relapse rates.
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References
Wiangnon S, Veerakul G, Nuchprayoon I, et al. Childhood cancer incidence and survival 2003-2005, Thailand: Study from the Thai Pediatric Oncology Group. Asian Pacific J Cancer Prev 2011;12:2215-20.
Seksarn P, Wiangnon S, Veerakul G, Chotsampancharoen T, Kanjanapongkul S, Chainansamit S. Outcome of childhood acute lymphoblastic leukemia treated using the Thai National protocols. Asian Pac J Cancer Prev 2015;16:4609-14.
Micheal ET, Harland NS, Gregory HR, et al. Leu Lymphoma.2008; 49:1142-54.
Cool J. Improvements in the survival of children and adolescents with acute lymphoblastic leukemia. Haematologica. 2012;97:635.
Vora A, Goulden N, Mitchell C, et al. Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukemia (UKALL 2003): a randomized controlled trial. Lancet Oncol 2014;15:809-18.
Larsen EC, Devidas M, Chen S, et al. Dexamethasone and high-dose methotrexate improve outcome for children and young adults with high-risk B-acute lymphoblastic leukemia:A report from Children’s Oncology Group study AALL0232. J Clin Oncol 2016;34:2380-8.
Eric WT, Kevin CW, Audrey B, David AS, Michel PC. Survival Among Children Diagnosed With Acute Lymphoblastic Leukemia in the United States, by Race and Age, 2001 to 2009:Findings From the CONCORD-2 Study. Cancer.2017;123(sup pl24):5178-89.
Wiangnon S. Veerakul G, Nuchprayoon I, et al. Childhood Cancer Incidence and Survival 2003-2005, Thailand: Study from the Thai Pediatric Oncology Group.Asian Pac J Cancer Prev. 2014;15:7989-93.
Wongmeerit P, Suwanrungruang K, Jetsrisuparb A, Komvilaisak P, Wiangnon S. Trends in Survival of Childhood Cancers in a University Hospital, Northeast Thailand, 1993-2012. Asian Pac J Cancer Prev. 2016;17: 3515-9.
BunUatisai W. Jia-Mahasap B and Chitapanarux I. Treatment Outcomes of Acute Lymphoblastic Leukemia in both Children and adults using the Thai Pediatric Oncology Group-based protocol at Chiang Mai University hospital. Journal of Thai Association of Radiation Oncology;2019;25: 12-28.
Howard SC, Pedrosa M, Lins M, et al. Establishment of a Pediatric Oncology Program and Outcomes of Childhood Acute Lymphoblastic Leukemia in a Resource-Poor Area. JAMA. 2004;26:2471-75.
Micheal ET, Harland NS, Gregory HR, et al. Leu Lymphoma.2008; 49:1142-54.
Cool J. Improvements in the survival of children and adolescents with acute lymphoblastic leukemia. Haematologica. 2012;97:635.
Suraponchai P, Pakakasama S, Sirachainan N, et al. Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience. Leuk Lymphoma. 2012;53:891-900.
Tharnprisan P, Khiewyoo J, Sripraya P, Wiangnon S. Relapse-free Rate with Childhood Acute Lymphoblastic Leukemia Treated under the Thai National Protocol. Asian Pacific Journal of Cancer Prevention. 2013;14:1127-30.
Kanjanaponkul S. Outcome of Acute Lymphoblastic Leukemia Teratment Using National Protocols at the Queen Siritkit National Institute of Child Health. J Med Assoc Thai. 2014;97(6):1.
Eric WT, Kevin CW, Audrey B, David AS, Michel PC. Survival Among Children Diagnosed With Acute Lymphoblastic Leukemia in the United States, by Race and Age, 2001 to 2009:Findings From the CONCORD-2 Study. Cancer.2017;123(sup pl24):5178-89.
Hussein H, Sidhom I, Naga SA, et al. Outcome and prognostic factors of acute lymphoblastic leukemia in children at the National Cancer Institute, Egypt. J Pediatr Hematol Oncol 2004;26:507-14.
Meirizkia A, Ayu DR, Indra RM, Sari DP. 3-year survival rate in acute lymphoblastic leukemia: comparison of ALL-2006 and ALL-2013 protocols. Paediatr Indones 2021;61:155-64.
Seraneeyanon L, Suwansigh S. Treatment outcome of acute lymphoblastic leukemia in children in Chiangrai Prachanukroh hospital. Thai Ped
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