A A​ case​ report ​of ​GBS ​meningitis​ in ​healthy​ adolescent

Abstract

Streptococcus agalactiae (Group B, β-hemolytic Streptococcus: GBS) is a common causative agent of infection in pregnant women, newborns, and children less than three-year-old. GBS has naturally colonized bacteria in the gastrointestinal and genitourinary tract of adults. Invasive GBS infection cases in non-pregnant adults had been a two to fourfold increase in two decades. Commonly, those were underlying individuals; diabetes mellitus, cancer, immunocompromised, and immunosuppressive drug use. Primary bloodstream infection (bacteremia without a localized source) is the most common manifestation of invasive GBS infection. While localized GBS infection, skin-soft tissue infection (subcutaneous abscess) is the most frequent form. GBS meningitis is a rare condition in adults (incidence is approximately 0.15 cases in 100,000 persons), the additional reported risk factors are craniotomy, cerebrospinal fluid leakage, infective endocarditis, and sexual intercourse.

This case report described GBS meningitis in the uncommon aged group; a male adolescent with no underlying disease and risk factor. He presented with high-grade fever and severe headache with photophobia and nuchal rigidity on physical examination. GBS was identified from cerebrospinal fluid and blood from culture (CSF latex agglutination of GBS was negative) leading to confirmed diagnosis of GBS meningitis and bacteremia. The appropriate antibiotic and supportive treatment were given to this patient. He was in complete recovery without sequelae.