Prognostic factors associated with mortality from septic shock in pediatric patients, Pattani Hospital
Keywords:
Sepsis, septic shock, child mortality, prognostic factor, metabolic acidosisAbstract
Background: Septic shock is one of the leading causes of death in children worldwide. Although there are diagnostic and treatment guidelines, the mortality rate of these conditions remains high.
Objective: To determine the prognostic factors associated with mortality from septic shock in pediatric patients.
Method: A retrospective study was conducted in the Pediatric Intensive Care Unit of Pattani Hospital. Patients aged 1 month to 15 years with a diagnosis of septic shock were enrolled between 1 January 2017 and 31 December 2021. The study compared survivors with non-survivors by t-test, Fisher's exact probability test, and multivariable logistic regression analysis.
Result: A total of 84 patients were enrolled in this study, 51 patients died during hospitalization. On multivariate analysis, the significant factors associated with mortality were 1. Progression of sepsis to septic shock within 7 days (risk ratio [RR] 5.59, 95% CI 2.07-15.09)), 2. Metabolic acidosis (RR 1.65, 95% CI 1.13-2.42)
Conclusion: Pediatric patients with sepsis should be closely monitored, especially within the first 7 days, and those with metabolic acidosis.
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