Chronic abdominal pain and diarrhea as the first clinical manifestations of childhood-onset systemic lupus erythematosus: A case report and literature review

Authors

  • Yos Werawatakul Department of Pediatrics, Khon Kaen Hospital
  • Phisek Yimyaem Department of Pediatrics, Khon Kaen Hospital
  • Amnuayporn Apiraksakorn Department of Pediatrics, Khon Kaen Hospital
  • Manasita Tanya Department of Pediatrics, Khon Kaen Hospital

Keywords:

chronic abdominal pain, diarrhea, Childhood-onset SLE, severe malnutrition

Abstract

Background: Clinical manifestations of systemic lupus erythematosus (SLE) are polymorphic, with involvement of various organs, leading to a delay in diagnosis. Gastrointestinal (GI) manifestations in SLE as the first symptoms in children are rare.

Case report: A 10-year-old girl presented with chronic abdominal pain, chronic diarrhea and severe malnutrition without other signs and symptoms. She was subsequently diagnosed with SLE by EULAR/ACR criteria. The patient was treated with corticosteroid and nutritional management. She recovered well, weight gained to normal and had no recurrence of GI symptoms during the last 12 months of follow-up.

Conclusion: Pediatricians should be aware of SLE in patients presenting with isolated GI manifestations.

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References

Malattia C. Paediatric-onset systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2013;27:351-62.

Petty RE. Systemic lupus erythematosus. In: Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, Mellins E, Fuhlbrigge R, editors. Textbook of pediatric rheumatology. 8th ed. Philadelphia: Elsevier; 2020. p. 396-449.

Tian XP, Zhang X. Gastrointestinal involvement in systemic lupus erythematosus: Insight into pathogenesis, diagnosis and treatment. World J Gastroenterol. 2010 28;16:2971-7.

Janssens P, Arnaud L, Galicier L, Mathian A, Hie M, Sene D, et al. Lupus enteritis: From clinical findings to therapeutic management. Orphanet J Rare Dis. 2013;8:67.

Santos MR. Diarrhea as First Symptom in Systemic Erythematous Lupus in Child - A Case Report. J Clin GastroenterolTreat[Internet].2016Sep30[cited7Mar2024];Availablefrom:https://clinmedjournals.org/articles/jcgt/journal-of-clinical-gastroenterology-and-treatment-jcgt-2-032.php?jid=jcgt

Aringer M. EULAR/ACR classification criteria for SLE. Semin Arthritis Rheum. 2019;49:S14-7.

Ebert EC, Hagspiel KD. Gastrointestinal and hepatic manifestations of systemic lupus erythematosus. J Clin Gastroenterol. 2011;45:436-41.

Kwok SK, Seo SH, Ju JH, Park KS, Yoon CH, Kim WU, et al. Lupus enteritis: Clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody. Lupus. 2007;16:803-9.

Fawzy M, Edrees A, Okasha H, El Ashmaui A, Ragab G. Gastrointestinal manifestations in systemic lupus erythematosus. Lupus. 2016;25:1456-62.

Fotis L, Baszis KW, French AR, Cooper MA, White AJ. Mesenteric vasculitis in children with systemic lupus erythematosus. Clin Rheumatol. 2016;35:785-93.

Yamazaki-Nakashimada MA, Rodriguez-Jurado R, Ortega-Salgado A, Gutierrez-Hernández A, García-Pavon-Osorio S, Hernandez-Bautista V. Intestinal pseudoobstruction associated with eosinophilic enteritis as the initial presentation of systemic lupus erythematosus in children. J Pediatr Gastroenterol Nutr. 2009;48:482-6.

Lepore L, Facchini S, Codrich D, Pelizzo G, Messineo A, Ventura A. Acute abdomen: The presenting sign of systemic lupus erythematosus in childhood. J Pediatr Gastroenterol Nutr. 2002;35:570-2.

Chowichian M, Aanpreung P, Pongpaibul A, Charuvanij S. Lupus enteritis as the sole presenting feature of systemic lupus erythematosus: Case report and review of the literature. Paediatr Int Child Health. 2019;39:294-8.

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Published

2024-03-29

How to Cite

Werawatakul, Y., Yimyaem, P. ., Apiraksakorn, A. ., & Tanya, M. (2024). Chronic abdominal pain and diarrhea as the first clinical manifestations of childhood-onset systemic lupus erythematosus: A case report and literature review. Thai Journal of Pediatrics, 63(1), 155–164. retrieved from https://he04.tci-thaijo.org/index.php/TJP/article/view/751