Factors associated with recurrent febrile seizures and epilepsy in pediatric patients with first-time febrile seizures at Supprasitthiprasong hospital
Keywords:
Febrile seizure, simple febrile seizure, complex febrile seizure, epilepsy, electroencephalographyAbstract
Introduction: Febrile seizures are a common pediatric condition with the potential for recurrence and the development of epilepsy.
Objective: This study aimed to identify factors associated with recurrent febrile seizures and the development of epilepsy in pediatric patients experiencing their first febrile seizure at Supprasitthiprasong Hospital.
Methods: A retrospective study was conducted on pediatric patients aged 6 months to 5 years who were diagnosed with a first episode of febrile seizure and admitted to Supprasitthiprasong Hospital from January 2019 to December 2021. Data was collected from the electronic medical record system.
Results: The study included 248 patients with a first episode of febrile seizure, comprising 141 males (56.9%) and 164 children under 18 months of age (66.1%). Recurrent febrile seizure occurred in 79 patients (31.9%). Upper respiratory tract infection was the predominant precipitating cause of the initial febrile seizure. Complex febrile seizures were diagnosed in 113 patients (45.6%). A family history of febrile seizures was noted in 37 patients (14.9%) and a family history of epilepsy was present in 5 patients (2%). Epilepsy developed in 5 patients. Statistically significant factors associated with recurrent febrile seizures included male sex, complex febrile seizures, and a family history of febrile seizures.
Conclusion: The factors associated with recurrent febrile seizures included male sex, complex febrile seizures, and a family history of febrile seizures.
Downloads
References
Steering Committee. Febrile Seizures: Clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008; 121:1281-6.
Shinnar S, Glauser TA. Febrile Seizures. J Child Neurol. 2002;17:44-52.
Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizure. N Engl J Med. 1976;295:1029-33.
Berg AT, Shinnar S, Hauser WA, Leventhal JM. Predictors of recurrent febrile seizures: A metaanalytic review. J Pediatr. 1990;116:329-37.
Fisher R, Acevedo C, Arzimanoglou A, et al. A practical clinical definition of epilepsy. Epilepsia. 2014 ;55: 475-82.
คณิตา อิสระภักดีรัตน์. ความชุกและปัจจัยเสี่ยงที่มีผลต่อการเกิดภาวะไข้ชักซ้ำหลังจากไข้ชักครั้งแรกในผู้ป่วยเด็กโรงพยาบาลสวรรค์ประชารักษ์. วารสารวิชาการแพทย์และสาธารณสุขเขตสุขภาพที่ 3. 2565; 19:156-67.
Ngamjarus C. Sample size calculation for health science research. 1 st ed. Khon kaen, Thailand: KhonKaen University Printing House; 2021.
Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of "febrile seizures": Ad Hoc Task Force of LICE Guidelines Commission. Epilepsia. 2009;50:2-6.
Kumar N, Midha T, Rao YK. Risk Factors of Recurrence of Febrile Seizures in children in a Tertiary care Hospital in Kanpur: A one year follow up study. Ann Indian Acad Neurol. 2019;22:31-6.
Berg AT, Shinnar S, Hauser WA, Alemany M, Shapiro ED, Salomon ME, Crain EF. A prospective study of recurrent febrile seizures. N Eng J Med. 1992;327:1122-7.
สุมิศรา อารีย์วัฒนานนท์. ปัจจัยที่มีผลต่อการเกิดไข้ชักซ้ำในผู้ป่วยเด็กโรคไข้ชักครั้งแรกของโรงพยาบาลหนองคาย. วารสารโรงพยาบาลมหาสารคาม. 2559;13:119-228.
Tosun A, Koturoglu G, Serdaroglu G, Polat M, Kurugol Z, Gokben S, et al. Ratios of nine risk factors in children with recurrent febrile seizures. Pediatr Neurol. 2010;43:177-82.
Canpolat M, Per H, Gumus H, Elmali F, Kumandas S. Investigating the prevalence of febrile convulsion in Kayseri, Turkey: An assessment of the risk factors for recurrence of febrile convulsion and for development of epilepsy. Seizure. 2018;55:36-47.
Renda R, Yüksel D, Gürer YK. Evaluation of patients with febrile seizure: Risk factors, recurrence, treatment and prognosis. Pediatr Emerg Care. 2020;36:173-7.
Maksikharin A, Prommalikit O. Recurrent rates and risk factors of febrile seizures in the subsequent illness following the first febrile seizures in Thai children. J Med Assoc Thai. 2019;102:62-6.
Indriani A, Risan N, Nurhayati T. Five years study of recurrent febrile seizure risk factors. AMJ. 2017;4:282-5.
Alinaghi K, Reza S, Ramazan F. The first febrile seizure; predisposing factors and recurrence rate. Iran J child Neurol. 2021;15:69-76.
Jeong JH, Lee JH, Kim K, Jo YH, Rhee JE, Kwak YH, et al. Rate of and risk factors for recurrence in patients with febrile seizures. Pediatr Emerg Care. 2014;30:540-5.
Civan AB, Ekici A, Havali C, Kilic N, Bostanci M. Evaluation of the risk factors for recurrence and the development of epilepsy in patients with febrile seizure. Arg Neuropsiquiatr. 2022;80:779-85.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 The Royal College of Pediatricians Of Thailand
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
