Kimura’s Disease: A case report

Abstract

Kimura’s disease is chronic inflammatory disorder of lymph node. Its classical manifestation is asymptomatic enlargement of lymph nodes predominantly of head and neck with eosinophilia. The diagnosis depends on the pathological findings, i.e. angiolymphoid hyperplasia with eosinophil infiltration of the lymph node, in combination with blood eosinophilia and increased serum immunoglobulin E. It can be principally treated by surgical correction. So far, it is still rare disease and here is one additional case. A 52-year old man presented with progressive painless mass confined within the left parotid gland area for a few months, no constitutional symptom. The mass was 10x10x2 cm, firm, without tenderness. Other physical examinations were within normal limit. The CBC, liver and kidney function tests were generally normal, except for eosinophilia and very high serum immunoglobulin E. The biopsy showed the angiolymphoid hyperplasia with eosinophil infiltration, which was consistent with Kimura’s disease. With oral prednisolone, the mass completely disappeared as well as eosinophilia within 2 months. He had been well for 4 years until Kimura’s disease with blood eosinophilia reappeared again. He still responded well to second course of oral prednisolone.