Diagnostic Accuracy of Core Needle Biopsy of Breast Lesions in Maharat Nakhon Ratchasima Hospital
Article Sidebar
Main Article Content
Abstract
Objective: To determine the accuracy, sensitivity and specificity of core needle biopsy of breast lesions in Maharat Nakhon Ratchasima Hospital. Material and Methods: The files of department of pathology, Maharat Nakhon Ratchasima hospital were searched for cases of breast lesions, between 1 October 2008 to 30 September 2010. Hematoxylin-eosin stained slides from manual core needle biopsy and subsequent open surgery specimens and their surgical pathology reports were retrospectively studied. The overall accuracy, sensitivity and specificity were analyzed. Results: One hundred and seventy cases with adequate tissue samples for histopathologic evaluation were included in this study. One hundred and sixty cases (94.12%) were correctly diagnosed by core needle biopsy compared with subsequent open surgery, In 114 cases, Invasive carcinomas were correctly diagnosed by core needle biopsy which mostly were invasive ductal carcinoma. Benign lesions were correctly proved in 46 cases which mostly were fibroadenoma. The accuracy of core needle biopsy in diagnosis of breast lesions was 94.11%. Conclusion: In this study, core needle biopsy yieldeds an accuracy rate of 94.11%. The sensitivity and specificity are 91.93% and 100% respectively. This is in line with several researches which report core needle biopsy as an excellent technique for palpable breast lesion creating high level of accuracy rate, sensitivity and specificity in performing a histological diagnosis of breast lesions.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Wilailak S. Epidemiologic report of gynecologic cancer in Thailand. J Gynecol Oncol 2009; 20:81-3.
Luechakiettisak P, Rungkaew P. Breast Biopsy: Accuracy of core needle biopsy compared with excisional or incisional biopsy: Prospecrive study. Thai Surg 2008; 29: 6-10.
Parker SH, Lovin JD, Jobe WE, Burke BJ, Hopper KD, Yakes WF. Nonpalpable breast lesions. Stereotactic automated large-core biopsies. Radiol 1991; 180: 403-7.
Dronkers DJ. Stercotaxic core biopsy of breast lesions. Radiol 1992; 183: 631-4.
Elvecrog EL, Lechner MC, Nelson MT. Nonpalpable breast lesions. Correlation of stereotaxic large-core needle biopsy and surgical biopsy results. Radiol 1993; 188: 453-5.
Parker SH, Burbank F, Jackman RJ, Aucreman CJ, Cardenosa G, Cink TM. Percutaneous large-core breast biopsy. A multi-institutional study. Radiol 1994; 193: 359-64.
Liberman L, Dershaw DD, Rosen PPl, Abramson AF, Deutch BM, Hann LE.. Stereotaxic core biopsy of breast carcinoma. Accuracy at predicting invasion. Radiology 1995; 194:379-81.
Meyer JE, Christian RL, Lcstcr SC. Evaluation of nonpalpable solid breast masses with stereotaxic large needle core biopsy using a dedicated unit. Am J Roentgenol 1996; 167: 179-82.
Nguyen M, McCombs MM, Ghandehari S. An update on core needle biopsy for radiologically detected breast lesions. Cancer 1996: 78:2340-5.
Brenner RJ, Fajardo L, Fisher PR. Percutaneous core biopsy of the breast. Effect of operator experience and number of samples on diagnostic accuracy. Am J Roentgenol 1996; 166: 341-6.
Seoudi H, Mortier J, Basile R, Curletti E. Stereotactic core needle biopsy of nonpalpable breast lesions. Initial experience with a promising technique. Arch Surg 1998; 133: 366-72.
Jackman RJ, Nowels KW, Rodriguez-Soto J, Marzoni FA Jr, Finkelstein SI, Shepard MJ. Stereotactic, automated, large core needle biopsy of nonpalpable breast lesions: False negative and histologic underestimation rates after long term follow-up. Radiol 1999; 210: 799-805.
Fajardo LL, Pisano ED, Caudry DJ, Gatsonis CA, Berg WA, Connolly J. Radiologist Investigators of the Radiologic Diagnostic Oncology GroupV: Stereotactic and sonographic large-core biopsy of nonpalpable breast lesions. Results of the Radiologic Diagnostic Oncology Group V study. Acad Radio 2004; 11: 293-308.
Brenner BJ, Bassett LW, Fajardo LL. Stereotactic core needle breast biopsy: A multi-institutional prospective trial. Radiol 2001; 218: 866-72.
Wiratkapun C, Fusuwankaya E, Wibulpholprasert B. Lertsittichai P. Diagnostic accuracy of vacuumassisted stereotactic core needle biopsy for breast lesions. J Med Assoc Thai 2010; 93: 1058-64.
Ivan D, Selinko V, Sahin AA, Sneig N, Middleton LP. Accuracy of core needle biopsy diagnosis in assessing papillary breast lesions: histologic predictors of malignancy. Modem Pathol 2004; 17: 165-71.
Verkooijen HM, Pecters PII, Duskens E, Koot VC, BoreI IH, Mali WP, et al. Diagnostic accuracy of large-core needle biopsy for nonpalpable breast disease: a meta-analysis. Br J Cancer, 2000; 82: 1017-21.
Youk JH, Kim E, Kim MJ. Missed breast cancers at US-guided core needle biopsy: How to reduce them. Radio Graphics 2007; 27: 79-94.
Bilous M. Breast core needle biopsy: issues and controversies. Modern Pathol 2010; 23:36-45.
Darvishian F, Singh B, Simsir A, Ye W, Cangiarella JF. Atypia on Breast Core Needle Biopsies: Reproducibility and Significance. Ann Clin Lab Sci Summer 2009; 39: 270-6.
Shannon J, Douglas A, Dallimore N. Conversion to core biopsy in preoperative diagnosis of breast lesions: is it justified by results? J Clin Pathol. 2001; 54: 762-5.
Verkooijen HM. Core Biopsy after Radiological Localisation (COBRA)Study Group: Diagnostic accuracy of stereotactic large-core needle biopsy for nonpalpable breast disease. Results of a multicenter prospective study with 95% surgical confirmation. Int J Cancer 2002; 99:853-9.
Jackman RJ, Nowels KW, Shepard MJ, Finkelstein Sl, Marzoni, FA Jr. Stereotaxic large-core needle biopsy of 450 nonpalpable breast lesions with surgical correlation in lesion with cancer or atypical hyperplasia. Radiol 1994; 193: 91-5.
Nath ME, Robinson TM, Tobon H. Chough DM, Sumkin JH. Automated large-core needle biopsy of surgically removed breast lesions: comparison of samples obtained with 14-,16-, and 18-gauge needles. Radiol 1995; 197: 739-42.
Rich PM, Michell MJ, Humphreys S, Howes GP, Nunnerley HB. Stereotactic 14G core biopsy of nonpalpable breast cancer.What is the relationship between the number of core samples taken and the sensitivity for detection of malignancy? Clin Radiol 1999;54: 384-9.
Liberman L, Dershaw DD, Rosen PP, Abramson AF, Deutch BM, Hann LE. Stereotaxic 14-gauge breast biopsy: how many core biopsy specimens are needed. Radiol 1994; 192: 793-5.