Treatment of Eosinophilia with Albendazole: A Pilot Study.
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Abstract
Twenty cases of eosinophilia of unidentified etiologies who had eosinophil count more than 1,000/mm3, no history of any allergic disease, normal physical examination, were alternatively allocated into 2 equal groups. The experimental group were treated with albendazole 2 tablets, 2 times a day for 7 days, compared with control group. Within 1 month, the eosinophil was re-evaluated. And it would be considered effective if the eosinophil was less than 1,000/mm3. In the experimental group, the effective rate was 70%, as compared to 10% of the control. No side effect was observed in both groups. In conclusion, albendazole was shown effective in case of eosinophilia without obvious causes.
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References
Holland SM, Gallin JI. Disorders of granulocytes and monocytes. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Internal Medicine. 16th ed. New York: Mc-Graw-Hill; 2005. p.349-57.
Cho JJ. Rate of persistent eosinophilia which incidentally founded after a follow up of 2 years in middle aged man. J Korean Acad Fam Med. 2001; 22: 1255-61.
Triteeraprapab S, Thamapanyawat B, Nuchprayoon I, Thanamun B. Eosinophilia with Iow prevalence of parasitism in a rural area of Maha Sarakham Province after annual mass treatment with mebendazole and albendazole. Chula Med J 2000; 44: 423 –31.
Teo CG, Singh M, Ting WC, Ong YW, Seet LC. Evaluation of the common conditions associated with eosinophilia. J Clin Pathol 1985; 38: 305-8.
Weller PF. Eosinophilia in travelers. Med Clin North Am 1992; 76: 1413-32.
Nutman TB, Ottesen EA, Ieng S, Samuels J, Kimball E, Lutkoski M, et al. Eosinophilia in Southeast Asian refugees: evaluation at a referral center. J Infect Dis 1987; 155: 309-13.
Tefferi A. Blood eosinophilia: a new paradigm in disease classification, diagnosis and treatment. Mayo Clin Proc 2005; 80: 75-83.
Libman MD, MacLean JD, Gyorkos TW. Screening for schistosomiasis, filariasis, and strongyloidiasis among expatriates returning from the tropics. Clin Infect Dis. 1993;
: 353-9.
Muennig P, Pallin D, Sell RL, Chan MS. The cost effectiveness of strategies for the treatment of intestinal parasites in immigrants. N Engl J Med. 1999; 340: 773-9.
Weller PF. Anthelminthic therapies. In: UpToDate, Rose, BD(Ed), UpToDate, Wellesly, MA, 2005.
Davies HD, Sakuls P, Keystone JS. Creeping eruption. A review of clinical presentation and management of 60 cases presenting to a tropical disease unit. Arch Dermatol 1993; 129: 588-91.
Sturchler D, Schubarth P, Gualzata M, Gottstein B, Oettli A. Thiabendazole vs. albendazole in treatment of toxocariasis: a clinical trial. Ann Trop Med Parasitol 1989; 83: 473-8.
Kraivichian P, Kulkumthorn M, Yingyourd P, Akarabovorn P, Paireepai CC. Albendazole for the treatment of human gnathostomiasis. Trans R Soc Trop Med Hyg 1992; 86: 418-21.
Kraivichian K, Nuchprayoon S, Sitichalernchai P, Chaicumpa W, Yentakam S. Treatment of cutaneous gnathostomiasis with ivermectin. Am J Trop 2004; 71: 623-8.
Cross JH, Basaca-Sevilla V. Albendazole in the treatment of intestinal capillariasis. Southeast Asian J Trop Med Public Health 1987; 18: 507-10.
Liu YH, Wang XG, Goa P, Qian MX. Experimental and clinical trial of albendazole in the treatment of Clonorchiasis sinensis. Chin Med J (Eng) 1991; 104: 27-31.
Kraivichian K, Nuchprayoon S, Siriyasatien P, Saksirisamphan W, Nuchprayoon I. Resolution of eosinophilia after treatment of cutaneous gnathostomiasis. J Med Assoc Thai 2005; 88 (Suppl 4): S163-6
Nuchprayoon S, Siriyasatien P, Kraivichian K, Porksakorn C, Nuchprayoon I. Prevalence of parasitic infections among Thai patients at the King Chulalongkorn Memorial Hospital, Bangkok, Thailand. J Med Assoc Thai 2002; 85 (Suppl 1): S415-23.
Jongsuksantigul P. Control of helminth infections of Thailand. Tropical Infectious disease: Now and Then 1997 The Medical Congress in Commemoration of the 50th Anniversary of the Faculty of Medicine, Chulalongkorn University, Bangkok ,Thailand, during June 3-6, 1997.
Triteeraprapab S, Nuchprayoon I, Eosinophilia, anemia. and parasitism in a ruralregion of NorthwestThailand. Southeast Asian J Trop Med Public Health 1998; 29: 584-90.
Bain BJ. Eosinophilia-idiopathic or not? N Engl J Med 1999; 341: 1141-3.