A Case of Pediatric Marfan Syndrome with Acute Myeloid Leukemia and Deep Vein Thrombosis

Authors

  • Pakin Kuakpetoon 1Third year pediatric resident from Department of Pediatrics, Khon Kaen Hospital
  • Su-on Chainansamit Pediatric Hematologist, Department of Pediatrics, Khon Kaen Hospital
  • Amnuayporn Apiraksakorn General Pediatrician, Department of Pediatrics, Khon Kaen Hospital
  • Supattra Somchit Pediatric Cardiologist, Department of Pediatrics, Khon Kaen Hospital

Keywords:

Marfan syndrome, Acute myeloid leukemia, Thrombosis

Abstract

We are demonstrating a 9-year-old girl, newly diagnosed Marfan syndrome, presented with deep vein thrombosis and acute myeloid leukemia. A few reports of Marfan syndrome with acute myeloid leukemia were published, none could identify correlation among them. To the best of our knowledge this would be the first pediatric case of Marfan syndrome with acute myeloid leukemia and thrombosis.

Downloads

Download data is not yet available.

References

Trachoo O. Diagnosis and Management of Marfan Syndrome. Rama Med J. 2014;37:209-18.

Judge DP, Dietz HC. Marfan’s Syndrome. Lancet. 2005; 366:1965–76.

Wiangnon S, Veerakul G, Nuchprayoon I, et al. Childhood cancer incidence and survival 2003-2005, Thailand: study from the Thai Pediatric Oncology Group. Asian Pac J Cancer Prev. 2011;12:2215-20.

Redner A, Kessel R. Lanzkowsky manual of pediatric hematology and oncology. 6th ed. London: Elsevier, 2016:390-406.

Hoppe C, Matsunaga A. Pediatric thrombosis. Pediatr Clin North Am. 2002;49:1257-83.

Chuansumrit A, Jarutwachirakul W, Sasanakul W, Rurgkhum S, Tardtong P, Hathirat P. Prevalence of Factor V Leiden in Thai Blood Donors. J Med Assoc Thai. 2001;84:489-93.

Colan SD, McElhinney DB, Crawford EC, Keane JF, Lock JE. Validation and re-evaluation of a discriminant model predicting anatomic suitability for biventricular repair in neonates with aortic stenosis. J Am Coll Cardiol. 2006;47: 1858-65.

Treatment protocol for low risk acute myeloidleukemia [ThaiPOG-AML-1301] in National protocol for the treatment of childhood cancers 2016. Bangkok, Thailand: ThaiPOG; 2016

Hsu C, Wang J, Liao W, et al. Association between malignancies and Marfan Syndrome: a population-based, nested case–control study in Taiwan. BMJ Open. 2017;7:e017243.

Sharief N, Kingston JE, Wright VM, Costeloe K. Acute leukemia in an infant with Marfan’s Syndrome: a case report. PediatrHematol Oncol. 1991; 8:323-7.

Lee JJ, Kim HJ, Chung IJ, et al. A case of Marfan Syndrome with acute monoblastic leukemia. Korean J Intern Med. 1998; 13:140-2.

Demir C, Bay A, Dilek I, Oner AF. Acute myeloblastic leukemia - associated Marfan Syndrome and Davidoff - Dyke - Masson Syndrome. Turk J Hematol. 2008; 25: 198-200.

Mehrvarz S, Hamrah H, Golmoradi M. Acute Myeloblastic leukemia and Marfan Syndrome: A Case Report and Literature Review. Int J Med Invest. 2018; 7:64-67.

John EH, George AS, Thaddeus EK, Edward R. Hypercoagulability in a patient with Marfan Syndrome. J Med Genet.1991;28:349-351.

Stefano VD, Sora F, Rossi E, et al. The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment. JTH. 2005;3:1985-92.

Furie B, Furie BC. Mechanism of thrombosis formation. N Engl J Med. 2008; 359: 938-49

cover-vol60no2

Downloads

Published

2021-06-30

How to Cite

Kuakpetoon, P. ., Chainansamit, S.- on, Apiraksakorn, A. ., & Somchit, S. (2021). A Case of Pediatric Marfan Syndrome with Acute Myeloid Leukemia and Deep Vein Thrombosis. Thai Journal of Pediatrics, 60(2), 159–164. retrieved from https://he04.tci-thaijo.org/index.php/TJP/article/view/1211

Issue

Vol. 60 No. 2 (2021): April-June 2021

Section

Case Report

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.