Prevalence and Clinical Outcomes of Antimicrobial use in Acute Diarrhea among Children under Twelve Years with Acute Diarrhea in Yasothon Hospital

Abstract

Objective: This research aims to investigate the prevalence of antibiotic use, clinical outcomes of treatment, including factors associated with irrational drug use in children under 12 years of age with acute diarrhea.
Method: A prospective cohort study was used in children under 12 years of age with acute diarrhea in Yasothon hospital. The instrument used was a questionnaire derived by researcher. General data analyze use descriptive statistics, clinical outcomes were compared by t-tests. Multiple logistic regression was used identify factors associated with irrational drug use. Conducted between January to April 2021.
Results: There were 257 samples, mostly of them were males, 54.9%, aged 0-5 years, 61.9% (mean age 5.1 years [SD 3.9]). The prevalence of antibiotic use was 37.7% (95%CI 31.8 to 43.7). Clinical outcomes between the treatment groups and did not receive antibiotics were no significant differences (p-value > 0.05). The prevalence of irrational drug use 60.3%. (95%CI 54.3 to 66.3). Three factors associated with irrational drug use: (1) age (6-12 years) (Adjusted OR 1.8, 95%CI 1.1 to 3.1) (2) type of person. sick (inpatient) (Adjusted OR 2.1, 95%CI 1.2 to 3.9) and (3) fever (Adjusted OR 2.5, 95%CI 1.4 to 4.4).                                                                                        Conclusions: The prevalence of antibiotic use was high. Clinical outcome suggests that antibiotic treatment in acute diarrhea may not be necessary. Factors associated with irrational drug use include age, patient type and fever symptoms. The results of this study can be taken into implementation of rational drug promotion in hospitals.