Treatment outcome and risk factors associated mortality of persistent pulmonary hypertension of newborn in sunpasitthiprasong hospital
Keywords:
Persistent pulmonary hypertension of newborn, outcome, mortalityAbstract
Introduction : Persistent pulmonary hypertension of newborn (PPHN) is a clinical characteristic to high pulmonary pressure and severe hypoxemia causing the circulation failure after birth and resulting in a high mortality and morbidity.
Objective : To determine treatment outcome and risk factors associated with mortality of persistent pulmonary hypertension of newborn in Sunpasitthiprasong hospital.
Methods : A retrospective observational cohort study was performed by reviewing medical records and data collection in information program of neonates with PPHN who were born ≥ 34 weeks gestation and admitted in Sunpasitthiprasong hospital between 1 October 2018 and 30 September 2020.
Results : Seventy-eight neonates with PPHN were enrolled. The mortality rate of PPHN was 41% (32 patients). Fifty-two neonates with PPHN (66.7%) were born by cesareanิ section and forty-two neonates with PPHN (53.8%) were born in Sunpasitthiprasong hospital. Sixty-seven neonates (85.9%) were diagnosed in 24 hours after birth. The most commoncause of PPHN was transient tachypnea of newborn 21 neonates (26.9%).The risk factors associated with mortality of PPHN were neonates being referred from other hospitals, high maximum oxygen index, used of high frequency oscillatory ventilator and neonates with ventilator associated pneumonia.
Conclusion : Persistent pulmonary hypertension of newborn is the important problem that associated with high mortality and morbidity. The high risk neonates should be observe closely and monitoring to prevent PPHN which resulting in decrease in mortality and morbidity
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