Percentage of body weight loss for predicting jaundice in term newborn infants
Keywords:
Body weight loss, Jaundice, hyperbilirubinemia, rebound neonatal jaundice, Suboptimal intake jaundice, Term infantAbstract
Background: Various problems cause neonatal jaundice. One of the common causes is suboptimal intake jaundice, which is caused by inadequate intake resulting in increased enterohepatic circulation and leading to hyperbilirubinemia. Singburi Hospital, which advocates exclusive breastfeeding, has observed a rise in hyperbilirubinemia cases necessitating prolonged hospital stays.
Objective: To explore the correlation between body weight loss and hyperbilirubinemia resulting in jaundice and to determine the prevalence of jaundice at Singburi hospital.
Methods: Term infants born between January 1, 2022 and March 31, 2023 were included in this retrospective descriptive study. Baseline characteristics were collected to evaluate risk factors associated with hyperbilirubinemia, including percentage of weight loss, and levels of unconjugated bilirubin. Analyze the data using independent t-test statistics. If any factor has a p value < 0.05, it will be further to analyzed in multiple logistic regression. Also, the optimal cutoff point between percentage body weight loss and hyperbilirubinemia was determined by utilizing a Receiver Operating Characteristic (ROC) curve.
Results: This study involved 707 term infants, including 364 males and 343 females. The prevalence of jaundice was 9.1% (64 patients). From ROC, the optimal cutoff point for predicting jaundice at 24 hours after birth was 4% body weight loss, which was statistically significant. [p=0.0014, Odds ratio; OR 2.09, AUC 0.559 (95%CI 0.481-0.637)].
Conclusion: This research can be used to develop guidelines for preventing jaundice in term newborns by promoting early successful breastfeeding management in the future.
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