Factors that influence the severity of allergic rhinitis and asthma in children in Phra Nakhon Si Ayutthaya province
Keywords:
Aeroallergen sensitization, pediatric asthma, allergic rhinitisAbstract
Background: Asthma is a major chronic condition in children globally, both urban and rural communities. The elements that influence the severity of the disease differ in each place.
Objective: To study factors affecting the initial severity of allergic rhinitis and asthma in children in Phra Nakhon Si Ayutthaya Province. To study the characteristics and trends of positive allergy skin tests to air allergens among patients with nasal allergies and asthma in children under 15 years of age in Phra Nakhon Si Ayutthaya Province.
Methods: This cross-sectional multicenter study collected data on children patients under the age of 15 from four medical facilities. Patients with allergic rhinitis (AR) and asthma diagnosed by a pediatric allergist were eligible for inclusion.
Results: There were 274 patients satisfied the research criteria. They were 159 allergic rhinitis patients, 54 asthma patients and 61 allergic rhinitis with asthma patients. One hundred and seventy three of males, 101 females, under the age of 15. We found that the severity of allergic rhinitis at first exposure was correlated with aeroallergen sensitivity to cats (p< 0.001, IRR = 1.42 (1.15 - 1.76)). The severity of asthma during the first episode was associated with aeroallergen sensitivity to Dermatophagoides farinae (p=0.049, IRR = 1.68 (1.01 - 2.8)) and exposure to indoor allergens (p=0.025, IRR = 1.71 (1.07 - 2.74)). Living in an industrialized or urban society is not statistical associated with the severity of disease, including AR and asthma. Common aeroallergen sensitization in allergic rhinitis patients were house dust mites, American cockroach, Cat while these in asthma were house dust mites, American cockroach, Paragrass, dog.
Conclusion: The severity of allergic rhinitis and asthma among children in Phra Nakhon Si Ayutthaya Province is mainly related to aeroallergen sensitization. Being an urban or industrial community has no clear effect on the severity of the disease.
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References
Bousquet J, Schunemann HJ, Togias A, Bachert C, Erhola M, Hellings PW, et al. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol. 2020;145:70-80.
Global Initiative for Asthma. Global strategy for asthma management and prevention [Internet]. 2023 [cited 2023 Jul 10]. Available from: https://ginasthma.org/wp-content/uploads/2023/07/GINA-2023-Full-report-23_07_06-WMS.pdf
Teague WG, Iqbal A, Ding Y, Chipps BE, Zazzali JL. The added burden of allergen sensitization among children with severe or poorly controlled asthma. J Allergy Clin Immunol Pract. 2021;9853-61.
Arrais M, Lulua O, Quifica F, Rosado-Pinto J, Gama JMR, Brito M, et al. Sensitisation to aeroallergens in relation to asthma and other allergic diseases in Angolan children: A cross-sectional study. Allergol Immunopathol (Madr). 2020;48:281-9.
Sritipsukho P. Aeroallergen sensitivity among Thai children with allergic respiratory disease: A hospital based study. Asian Pac J Allergy Immunology. 2004 ;22:91-5.
Visitsunthorn N, Chaimongkol W, Visitsunthorn K, Pacharn P, Jirapongsananuruk O. Great flood and aeroallergen sensitization in children with asthma and/or allergic rhinitis. Asian Pac J Allergy Immunol. 2018;36:69-76.
Tantilipikorn P, Pinkaew B, Talek K, Assanasen P, Triphoon Suwanwech TS, Bunnag C. Pattern of allergic sensitization in chronic rhinitis: A 19-year retrospective study. Asian Pac J Allergy Immunol. 2021;39:156-62.
Yuenyongviwat A, Koonrangsesomboon D, Sangsupawanich P. Recent 5-year trends of asthma severity and allergen sensitization among children in southern Thailand. Asian Pac J Allergy Immunol. 2013;31:242-6.
Lejeune S, Bouazza N, Nicaise PR, Jolaine V, Roditis L, Marguet C, et al. COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease? Pediatr Allergy Immunol. 2024;35:e14112.
Di Cicco M, Del Tufo E, Fasola S, Gracci S, Marchi MG, Fibbi L, et al. The effect of outdoor aeroallergens on asthma hospitalizations in children in north-western Tuscany, Italy. Int J Environ Res Public Health. 2022;19:3586.
Lee E, Song DJ, Kim WK, Suh DI, Baek HS, Shin M, et al. Associated factors for asthma severity in Korean children: A Korean Childhood Asthma Study. Allergy Asthma Immunol Res. 2020;12:86-98.
Lezmi G, Lejeune S, Pin I, Blanchon S, Bouazza N, Jolaine V, et al. Factors associated with asthma severity in children: Data from the French COBRAPed Cohort. J Allergy Clin Immunol Pract. 2021;9:1969-79.
Mendes AP, Zhang L, Prietsch SO, Franco OS, Gonzáles KP, Fabris AG, et al. Factors associated with asthma severity in children: A case-control study. J Asthma. 2011;48:235-40.
Mock K, Palma AM, Wu J, Billimek J, Lu KD. Breathing Room: Industrial zoning and asthma incidence using school district health records in the city of Santa Ana, California. Int J Environ Res Public Health. 2022;19:4820.
Ripabelli G, Tamburro M, Sammarco ML, de Laurentiis G, Bianco A. Asthma prevalence and risk factors among children and adolescents living around an industrial area: A cross-sectional study. BMC Public Health. 2013;13:1038.
กรมควบคุมมลพิษ. รายงานสภาพอากาศตามภูมิภาค [อินเทอร์เน็ต]. 2567 [เข้าถึงเมื่อ 10 เมษายน 2567]. เข้าถึงได้จาก: http://air4thai.pcd.go.th/webV3/#/Home
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