Associated factors and outcomes of persistent pulmonary hypertension of the newborn in Lampang hospital
Keywords:
persistent pulmonary hypertension of the newborns, respiratory distress in newborns, maternal health conditionsAbstract
Background: The study of risk factors for persistent pulmonary hypertension of the newborns can help develop guidelines for monitoring, diagnosis, and treatment to reduce morbidity and mortality, as well as improve healthcare systems in health districts.
Objective: To study the factors associated with persistent pulmonary hypertension of the newborns and the outcomes of treatment.
Method: A retrospective study was conducted to compare the persistent pulmonary hypertension of the newborns with other causes of respiratory distress from 2018 to 2024. Multivariable risk difference regression analysis was used to analyze factors affecting persistent pulmonary hypertension of the newborns.
Results: Factors affecting persistent pulmonary hypertension of the newborns included cesarean delivery (RR 1.92; 95%CI 1.17, 3.13), meconium aspiration syndrome (RR 3.46; 95%CI 1.97, 6.08), neonatal sepsis (RR 2.53; 95%CI 1.51, 4.23), pulmonary hemorrhage (RR 2.47; 95%CI 1.39, 4.37), pneumothorax (RR 2.33; 95%CI 1.41, 3.84), and heart failure due to patent ductus arteriosus (RR 4.85; 95%CI 3.16, 7.46). The group with persistent pulmonary hypertension of the newborns required more inotropic drugs, vasodilators, and high-frequency ventilation. They had longer ventilation times, longer hospital stays, and higher mortality rates, all of which were statistically significant.
Conclusion: The method of delivery, conditions affecting the heart and lungs, and bloodstream infections were associated with pulmonary hypertension. Therefore, controlling these factors might help reduce persistent pulmonary hypertension of the newborns, which could impact disability and mortality.
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