Mikulicz’s Syndrome: A case report
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Abstract
Mikulicz’s syndrome is characterized by the symmetrical enlargement with lymphocytic infiltrations of the parotid salivary glands and the lacrimal glands.Its common causes are lymphoma, and other autoimmune diseases. So far, it has been rarely reported therefore we additionally report one case in a Thai patient. He was a 65-year-old Thai presenting with the gradual enlargement of multiplemasses at both eye brows, both parotid glands and both sides of the cervical lymph nodes within a few months without local or constitutional symptoms.The size of the masses varied, 2-3 cm, firm consistency, no fluctuation, and no tenderness. No lymph nodes at other parts of the body were found on the physical examination, theultrasonography of the upper abdomen and the chest filmexcept the small pretracheal lymphadenopathies found on the computed tomography of the chest. The blood tests for anti-SSA and anti-SSB antibodies were found negative.The microscopic pathology of the cervical lymph node was shown to be the atypical lymphoid hyperplasia, suggestive of Hodgkin disease, mixed cellularity.He was diagnosed as having Mikulicz’s syndrome, with an underlying Hodgkin’s lymphoma, mixedcellularity at least stage IIA. After the multi-drugchemotherapy, allmassesdisappeared within only one course. Because this case had no anti-SSA, anti-SSB antibodies and no kerato-conjunctivitis sicca, it seemed to support the proposal that Mickulicz’ s syndrome and Sjogren’s syndrome are different entities.
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