Congenital Factor VII Deficiency: A Case Report and Review Literatures
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Abstract
A case of 18 days old female infant was referred to Maharat Nakhon Ratchasima Hospital with hematoma at dorsum of left hand and multiple ecchymosis at arms and legs. Coagulogram showed prolong prothrombin time (54.7 sec [10.0-15.1 sec]), INR 4.27, activated partial thormboplastin time 49.3 sec [29.5-45.5 sec], Thrombin time 18.2 sec [14.0-21.0 sec]. Ultrasound of the brain and CT scan of the brain showed old intracerebral hemorrhage. Factor VII level is 2% confirmed congenital factor VII deficiency. She received replacement therapy with fresh frozen plasma to stop her bleeding then prophylaxis further bleeding with fresh frozen plasma 3 times per week.
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