Primary Cerebellar NonHodgkin’s Lymhoma in Non-HIV Patient: The Rare Extranodal Lymphoma.
Article Sidebar
Main Article Content
Abstract
Primary cerebellar nonHodgkin’s lymphoma (NHL) in immuno-competent patient is very rare disease. Here we report one case of isolated NHL in the cerebellum. The patient was a Thai man, 56 years of age. He gradually developed progressive vertigo, headache and truncal ataxia for 2 weeks. He also had occasional vomiting, but no fever or weight loss. Physical examination confirmed that he had truncal ataxia and dysmetria, no other lymph node or hepatosplenomegaly. With the computerized tomography of the brain, a solitary cerebellar tumor was demonstrated and it was nearly all excised under general anesthesia. The pathology was diffuse large B cell lymphoma. Bone marrow study was normal. He was diagnosed as primary isolated cerebellar nonHodgkin’s lymphoma. After operation, he was treated with irradiation, systemic chemotherapy plus intrathecal cytosine arabinoside. At6-month follow-up, he could walk with limping gait and still survived 11 months when this reported was performed.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Krol ADG, le CessieS, Snijder S, Kluin-Nelemans JC, Khuin PM, Noordijk EM. Primary extranodal non-Hodgkin's lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population-based NHI. registry. Ann Oncol 2003; 14: 131-9.
Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal Iymphomas. Cancer 1972; 29:252-60.
White BE, Rothfleisch S. Primary cerebellar lymphoma. A case report. Neurology 1968; 18: 582-6.
Cha MH, Hwang SN, Kim BJ, Chi JG. A case of malignant lymphoma of the cerebellum. J Korean Neurosurg Soc 1981; 10: 619-24.
Sasahara A, Kawamata T, Kubo O, Okami N, Kawamura H, Hori T.Primary CNS malignant lymphoma originating from the cerebellum and extending along the lower cranial nerves. No Shinkei Geka 2000; 28:879-83.
Taya K, Terao T, Tanaka T, Sawauchi S, Numoto RT, Murakami S,etal. Spontaneous regression of primary central nervous system Iymphoma: a case report. No Shinkei Geka 2004; 32: 637-42.
Pirumyan G, Bakshi N, Fung KM. A 67-year-old woman with a cerebellar and a parictal cnhancing lesions. Available at: http://moon.ouhsc.edu/kfung/JTY1/Com07/Com706-1-Diss.htm
Ramachandran TS. Primary CNS Lymphoma. Available at:http://www.emedicine.com/neuro/TOPIC519.HTM
Miller DC, Hochberg FH, Harris NL, Gruber ML, Louis DN, Cohen H. Pathology with clinical correlations of primary central nervous system non-Hodgkin's lymphoma. The Massachusetts General Hospital experience 1958-1989. Cancer 1994; 74: 1383-97.
Fertikh D, Artman CE, Brooks ML. Brain lymphoma. Available at: http://emedicine.medscape.com/article/338139-overview.
Garcia ME, Garcia AM, Catalan MJ. Primary cerebral lymphoma in an immunocompetent patient. Neurologia 2008; 23: 122-5.
Fisher RI, Gaynor ER, Dahlberg S, Oken MM, Grogan TM, Mize EM, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced Non-Hodgkin's lymphoma. N Engl J Med 1993; 328: 1002-6.
Lachance DH, Gockerman J, Halperin E. Cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) for primary central nervous system lymphoma (PCNSL): short-duration response, multi-focal intracerebral recurrence preceding radiotherapy. Neurology 1992;42(Suppl 3): 343.
Hochberg FH, Batchelor TB, Loeffler JS. Clinical and pathologic features of primary central nervous system lymphoma. In: UpToDate, Basow, DS(Ed), UpToDate, Waltham, MA, 2008.