Cerebral Venous Thrombosis due to Protein C or Protein S Deficiency: Report of Six Cases and Literature Review
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Abstract
In the present day the novel risk factors for developing cerebral venous thrombosis have been found. The inherited prothrombotic diseases such as protein C or protein S deficiency are the causes of this condition. In Thai population, the clinical data of this condition due to protein C or protein S deficiency have never been investigated. The author had reported six cases of cerebral venous thrombosis due to protein C or protein S deficiency at Maharat Nakhon Ratchasima Hospital. The literatures were reviewed to compare the clinical data of cerebral venous thrombosis from any cause and from protein C or protein S deficiency. The baseline characteristics such as age, sex and risk factors, symptoms and signs were not different between patients with and without protein C or protein S deficiency. The good outcomes of the treatment with anticoagulant were found in both groups.
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References
Ameri A, Bousser MG. Cerebral venous thrombosis. Neurol Clin 1992; 10: 87-111.
Stam J. Thrombosis of the cerebral veins and sinus. N Engl J Med 2005; 352: 1791-8.
Masuhr F, Mehraein S, Einhaupl K. Cerebral venous and sinus thrombosis. J Neurol 2004; 251: 11–23.
Poungvarin N, Prayoonwiwat N, Ratanakorn D, Towanabut, Tantirittisak S, Suwanwela N, et al. Thai Venous Stroke Prognostic Score. J Med Assoc Thai 2009; 92: 1413-22.
Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
Liu HW, Kwong YL, Bourke C. High incidence of thrombophilia detected in Chinese patients with venous thrombosis. Thromb Haemost 1994; 71: 416-9.
Zoller B, Berntsdotter A, Garcia de Frutos P, Dahlback B. Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. Blood 1995; 85: 3518-23.
Akkawat B, Rojnuckarin P. Protein S Deficiency is Common in a Healthy Thai Population. J Med Assoc Thai 2005; 88(Suppl 4): S249-S254.
Sanson BJ, Friederich PW, Simioni P, Zanardi S, Hilsman MV, Girolami A, et al. The risk of abortion and stillbirth in antithrombin III, protein C and protein S deficient women. Thromb Haemost 1996; 75: 387-8.
Vandenbroucke JP, Rosing J, Kitty WM, Middeldorp S, Helmerhorst FM, Bouma BN, et al. Oral contraceptive and the risk of venous thrombosis.N Engl J Med 2001; 344: 1527-35.
Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Blood. 2004; 103: 1192-201.
Goodwin AJ, Rosendaal FR, Kottke-Marchant K, Bovill EG. A review of the technical, diagnostic, and epidemiologic considerations for protein S assays. Arch Pathol Lab Med 2002; 126: 1349-66.
Ferro JM, Canhao P, Stam J, Bousser MG, Barinagarrementeria F. Prognosis of Cerebral Vein and Dural Sinus Thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664-70.