Risk Factors for Recurrent Febrile Seizures within A Single Episode of Febrile Illness
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Abstract
Background: Febrile seizures are found prevalently 2 to 5 percent of all febrile children. This particular syndrome is resulted from a combination of genetic and environmental factors. To date, there are several studies exploring the risk factors of recurrent febrile seizures but only few exploring associated factors for repeated seizures within a single episode of febrile illness. Objective: To find out the associated factors of recurrent seizures within a single episode of febrile illness. Patients & Methods: Patients diagnosed with febrile seizures ranging from 3 months to 5 years old who were hospitalized in Maharat Nakhon Ratchasima Hospital from October, 29th 2006 to October, 28th 2007 were included in this cross-sectional study. Clinical data were collected from their medical records and supplementary information was carried out by the interview with their caregivers. Results: Totally 111 patients were included in this study. Recurrent seizures within one febrile episode were found in 31 of 111 cases (27.9 percent). Particularly, the tendency of this event appeared to be associated with family history of epilepsy (odds ratio=12.3, 95% CI 1.73-87.61) and female gender (odds ratio=1.1, 95% CI 1.20-7.73). The other factors, i.e., age less than 18 months, previous history of febrile seizures, family history of febrile seizures, temperature > 39บC, duration of fever before seizure, and lower serum sodium level were not associated with recurrent seizures. Conclusions: Family history of epilepsy and female gender are implied as the associated factors to increase recurrent seizures within the single episode of febrile illness.
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