Breast Cancer at Maharat Nakhon Ratchasima Hospital: a 2-Year Review
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Abstract
Background: Breast cancer is the second most common cause of cancer among Thai women. Delay in diagnosis and treatment of breast cancer lead to progression of the disease to late stage and is associated with high mortality Objective: To report the characteristic, tumor size, tumor stage and ratio of operative procedure between breast conservative therapy (BCT) and modified radical mastectomy (MRM) in early invasive breast cancer Patients & Methods: Retrospective analytic study was performed in 238 breast cancer patients who underwent operations at Maharat Nakhon Ratchasima Hospital, between January, 2006 and December, 2007. Results: The majority of patients are 41-50 years olds, mean 50.5 + 11.1 years (mean+SD), most common presentation was breast mass 77.2%, site of tumor was most common at upper outer quadrant 57.1%, the primary tumor was common in T1 55.5%, most common tumor were stage IIA and IIB, 28.9% and 22.7% respectively. The match ratio of BCT : MRM was 1 : 15.8. Conclusion: Breast cancer in woman in Maharat Nakhon Ratchasima Hospital were common in the 41-50 year-old most common presentation was breast mass at upper outer quadrant 57.26%. Most common tumor was stage IIA and IIB. MRM was the most common operative procedure in early invasive breast cancer (Stage I, IIA IIB). The match ratio of treatment was 1 : 15.8 for BCT : MRM.
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References
Chaiwerawatana A. Breast. Cancer in Thailand: Vol IV. [cited 2008 Apr 30]. Available from: URL: http://www.nci.go.th/Filedownload/Cancer%20In%20Thailand%20 IV/C-II-13.PDF
Morabia A, Wynder EL. Epidemiology and natural history of breast cancer. Implications for the body weight breast cancer controversy. Surg Clin North Am 1990; 70: 739-52.
ธรรมนิตย์ อังศุสิงห์. Screening mammography: when for Thai women? ใน: ศุภกร โรจนนินทร์, อดุลย์ รัตนวิจิตราศิป์, กริช โพธิสุวรรณ, วารินทร์ ตัณฑ์ศุภศิริ, บรรณาธิการ. Head, neck and breast surgery (2). กรุงเทพมหานคร: เรือนแก้ว; 2543. หน้า 306-24.
Tabar L, Fagerberg CJ, Gad A, Baldetorp L, Holmberg LH, Gr๖ntoft O, et al. Reduction in mortality from breast cacer after mass screening with mammography. Randomized trial from breast cancer screening working group of the Swedish National Board of Health and Welfare. Lancet 1985; 1: 829-32.
Elwood JM, Moorehead WP. Delay in diagnosis and long term survival in breast cancer. Br Med J 1980; 280: 1291-4.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005; 365: 1687-717.
Baum M, Budzar AU, Cuzick J, Forbes J, Houghton JH, Klijn JG, et al; ATAC Trialists’ Group. Anastrozole alone or incombination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: first results of the ATAC randomized trial. Lancet 2002; 359: 2131-9.
Thurlimann B, Keshaviah A, Coates AS, Mouridsen H, Mauriac L, Forbes JF, et al: A comparison of letrozole and tamoxifen in postmenopausal woman with early breast cancer. N Engl J Med 2005; 353: 2747-57.
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353: 1673-84.
Piccart-G ebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, et al. Trastuzumab after adjuvant chemotherapy in HER2 positive breast cancer. N Engl J Med 2005; 353: 1659-72.
Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347: 1233-41.
Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002; 347: 1227-32.
Benson EA. Symptom and signs of operable breast cancer 1997-1981. Br J Surg 1983; 70: 350-3.
กฤษณ์ จาฏามระ. Diagnosis of breast cancer.ใน: ณรงค์ไวท์ยางกูล, กิตติ เย็นสุดใจ, อวยชัย เปลื้องประสิทธ์, ทองดี ชัยพานิช, บรรณาธิการ. ศัลยศาสตร์วิวัฒน์ (10). กรุงเทพมหานคร:กรุงเทพเวชสาร; 2535. หน้า 168-88.
Thongsuksai P, Chongsuvivatwong V, Sriplung H. Delay in breast cancer care: a study in Thai women. Med Care 2000; 38: 108-14.
Ernster VL, Barclay J, Kerlikowske K, Grady D, Henderson C. Incidence and treatment for ductal carcinoma in situ of the breast. JAMA 1996; 275: 913-8.
อดุลย์ รัตนวิจิตราศิลป์. Management of DCIS; non- palpable & clinicaly palpable.ใน: ศุภกร โรจนนินทร์, อดุลย์รัตนวิจิตราศิป์, กริช โพธิสุวรรณ, วารินทร์ ตัณฑ์ศุภศิริ, บรรณาธิการ. Head, neck and breast surgery (2). กรุงเทพ มหานคร: เรือนแก้ว; 2543. หน้า 345-52.
Fan J, Wang L, Wang XJ, Wu J, Lu JS, Di GH, et al. Breast conservative therapy in east part of China: a retrospective cohort study. J Cancer Res Clin Oncol 2006; 132: 573-8.