Genetic Amniocerntesis for Prenatal Diagnosis in Maharat Nakhon Ratchasima Hospital: Budget Year2005-2006

Abstract

          Nowadays, Amniocentesis for prenatal diagnosis of chromosome abnormality is frequently serviced. In year 2003, this service was started in Maharat Nakhon Ratchasima Hospital. Objective: To evaluate amniocentesis for prenatal diagnosis of chromosome abnormality in Maharat Nakhon Ratchasima Hospital. Materials & Methods: Retrospective descriptive study in the pregnant women who received the amniocentesis for prenatal diagnosis of chromosome abnormality at prenatal unit, Department of Obstetrics and Gynecology, Maharat Nakhon Ratchasima Hospital during October 1, 2004 to September 30, 2006 (2 budget years). The data were analyzed. Results: 427 pregnant women who underwent genetic amniocentesis and abnormality in chromosome was found in 11 persons (2.6%). The most common indication was maternal age over 35 years old (95.3%). The complication was found 0.5%; 1 abortion in normal karyotype and 1 fetal death in utero in trisomy 21 (47XY, +21); and fetal cell culture failure was found in 3 cases (0.7%). Conclusion: Genetic amniocentesis in Maharat Nakhon Ratchasima Hospital was highly successful with low complication it was safe method in prenatal diagnosis of chromosome abnormalities. By this method, chromosome abnormality was found 2.6%.