Associated factors of Gestational Trophoblastic Disease: 5 Year Experience in Buddhachinaraj Phitsanulok Hospital

Abstract

Introduction: Gestational trophoblastic disease (GTD) consists of molar pregnancy and choriocarcinoma. It is derived from abnormal proliferation of pregnancy related trophoblastic cell. It is more frequently found in oriental 5-10 times than in western world. Objective: To verify the relationship between its occurrence and numbers of pregnancy as well as maternal age and to identify its leading problems. Patients & Methods: Medical records of GTD in Buddhachinaraj Phitsanulok Hospital, Phitsanulok during 2000-2004 were retrospectively reviewed and compared to control. The control group was randomly selected from normal pregnant women who attended antenatal care within the same month and year as GTD. Results: The prevalence of GTD was 1.75:1,000, it did not relate to maternal age (p>0.05). Mean age was 26.7 ± 10.2 years. About numbers of pregnancy, in cases of more than 2, every pregnancy could significantly raise 1.5 folds of the risk of GTD (p<0.05). The most common leading problem was spotted vaginal bleeding (63.6%), the second common was spotted bleeding with frank mole (13.6%). Conclusion: During year 2000-2003, 22 GTD cases were diagnosed in Buddhachinaraj Phitsanulok Hospital, Phitsanulok by pathologist. Mean age was 26.7 ± 10.2 years. Its occurrence was found relating to numbers of pregnancy, not to maternal age.