Clinical Efficacy of Clindamycin Phosphate Injection in Serious Skin and Soft Tissue Infect

Abstract

Severe infection of skin and soft tissue (e.g. Cellulitis, Necrotizing fasciitis) is a common infectious problem. Clindamycin is well established drug of choice. An objective of this study is to determine the efficacy and side effects of a local made Clindamycin, intravenous form with this kind of infection. Of 20 patients with severe skin and soft tissue infections (14 with cellulitis and 6 with necrotizing fasciitis) were treated with a local made Clindamycin, and 45 % of cases were treated with the combination of Clindamycin and third generation cephalosporin Ceftriaxone, Cefotaxime). The clinical outcomes were improved in 50 % of patients after 3 days (temperature declined, sign and symptoms of infection were alleviated) and all treatments were switched to oral antibiotics (95% Clindamicin alone) after 7 days of treatments All patients had no sign and symptoms of infection after 14 days of treatment. None of the patient had diarrhea or other side effect and the laboratory test for liver and renal function appeared normal after treatment. Conclusion: A local made clindamycin has good efficacy and safety for severe infection of skin and soft tissue without side effect.