Radiation Treatment of Spinal Cord Compression from Extramedullary Hematopoiesis in Thalassemia: Report of 3 Cases
Article Sidebar
Main Article Content
Abstract
During September 1993-January1998, Division of Radiation Oncology, Department of Radiology, Maharat Nakhon Ratchasima Hospital had three male thalassemic patients with neurological symptom of spinal cond compression due to extramedullary hematopoiesis in thoracic spine. These patients were treated with radiotherapy using total radiotherapeutic doses between 1,600-2,000 cGy in 8-10 fractions and the result of trent was excellent. Radiotherapy should be the treatment of choice in thalassemic patients with symptom of spinal cord compression from extramedullary hematopoiesis. Doses of radiotherapy which are adequate for treatment should not exceed 2,000 cGy in 10-12 fractions.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Wintrobe MM.Clinical haematology.8th edition. Phiadelphia: Lea & Febiger;1974.
Brannan D Extramedullary hematopoeisis in anemias. Bull John Hopkins Hosp 1927;41:104-6.
Gatto I, Terrana V, Biondi L.Compressione sul midollo spinale da proliferazione di midollo osseo nello spazio epidurale in soggetto affetto da malattia di Cooley splenectomiz-zato. Haematologica 1954;38:61-76.
Close AS, Taira Y, Cleveland DA. Spinal cord compression due to extramedullary hematopoiesis. Ann Intern Med 1958; 48:421-7.
Ross P, Logan W. Roentgen findings in extramedullary hematopoeisis. Am J Roentgenology 1969;106:604-13.
Leigh TF, Weens HS. The mediastinum. Springfield I11.: Charles C Thomas;1959:235.
Lowman RM, Bloor CM, Newcomb AW. Roentgen manifestation of thoracic extramedullary hematopoiesis. Dis Chest 1963;44:154-62.
Issaragrisil S, Piankijakum A, Wasi P. Spinal cord compression in thalassemia. Report of 12 cases and recomendation for treatment. Arch Intern Med 1981;141:1033-6.
Sorsdahl OS, Taylor PE, Noyes D.Extramedullary hemato-poiesis, mediastinal masses and spinal cord compression. JAMA 1964;3:343-7.
Papavasiliov CG.Correspondance: radiotherapy of symptomatic tumor-simulating extramedullary hemopoeisis. Int J Radiat Oncol Biol Phys 1982;8:1831-4.
Chansilpa Y,Pattaranutaporn P. Radiation treatment of spinal cord compression from extramedullary hemopoiesis in thalassemia. Thai I Radiol 1993;30:59-64.
Lau SK, Chan CK, Chow YY. Cord compresion due to extramedullary hemopoiesis in a patient with thalassemia. Spine 1994;19:2467-70.
Shin KH, Sharma S, Gregoritch SJ, Lifeso RM, Bettigole R,Yoon SS.Combined radiotherapeutic and surgical management of a spinal cord compression by extramedullary hematopoiesis in a patient with hemoglobin E beta- thalassemia. Acta Haematol 1994;91:154-7.
Cardia E, Toscano S, La Rosa G, Zaccone C, d' Avella D, Tomasello F. Spinal cord compression in homozygous beta-thalassemia intermedia. Pediatr Neurosurg 1994;20:186-9.
Parsa K, Oreizy A.Nonsurgical approach to paraparesis due to extramedullary hematopoiesis: report of two cases. J Neurosurg 1995;82:657-60.
Lee AC, Chiu W, Tai KS, Wong V,Peh WC, Lau YL. Hy-pertransfusion for spinal cord compression secondary to extramedullary hematopoiesis. Pediatr Hematol Oncol 1996; 13:89-96.