Risk factors relating to recurrent febrile seizures in Pediatric patients At Phaholpolpayuhasena hospital

Abstract

Febrile seizure is the most common seizure disorder in children, approximately one-third of them develop a recurrent of febrile seizure. And some studies have shown that there may be an increased risk of epilepsy Objectives: To identify risk factors relating to recurrent febrile seizures and determine incidence of epilepsy after recurrent febrile seizures in pediatric patients at Phaholpolpayuhasena hospital. Methods: A retrospective study was performed by recruiting the children who presented with first febrile seizure at Phaholpolpayuhasena hospital between January 1^st 2016 and December 31^st 2018. The data were recorded and analysed with chi-square, Fisher’s exact test and multiple logistic regression analysis.

Results: There were 355 children who presented with first episode febrile seizures, 106 of them had recurrence. The study indicated that a family history of febrile seizures were associated with an increased risk of recurrent febrile seizures and multiple logistic regression analysis revealed that a positive family history was significantly higher in children with recurrent febrile seizures, compared with those without recurrent febrile seizures with odds ratio of 2.35 (OR=2.35, 95% CI=1.418-3.905, P=0.001). Additionally, the study had showed that the incidence of epilepsy in children with recurrent febrile seizures were 8.5% that higher than those without recurrence with statistical significance.    

Conclusion: A family history of febrile seizure was risk factors of recurrent febrile seizures in children and a history of recurrent febrile seizures appeared to be associated with a risk of epilepsy.