ผลกระทบของการใช้แอมเฟตามีนในหญิงตั้งครรภ์เดี่ยวต่อผลลัพธ์ของมารดา และทารกแรกเกิดโดยการศึกษาแบบย้อนหลังในโรงพยาบาลพหลพลพยุหเสนา กาญจนบุรี

Pailin Tunchotiwet

Authors

Pailin Tunchotiwet Department of Obstetrics and Gynecology, Phaholpolpayuhasena Hospital, Kanchanaburi 71000

Keywords:

pregnancy, neonatal outcomes, pregnancy outcomes, amphetamine

Abstract

Objectives: To investigate the maternal and neonatal outcomes of amphetamine use in singleton pregnancies

Methods: A retrospective cohort study was conducted using medical records of singleton pregnant women who delivered at Phaholpolpayuhasena Hospital, Kanchanaburi, Thailand, between January 1, 2020, and December 31, 2024. A total of 200 cases were included: 100 with positive urine methamphetamine tests and 100 controls. Data was analyzed by using descriptive and inferential statistics.

Results: Amphetamine-exposed pregnant women group had a higher rate of no antenatal care (48.00% vs 3.00%, p<0.001). Regarding maternal outcomes, higher rates of normal labor (75.00% vs 56.00%, p=0.005), lower estimate blood loss (187.50 vs 238.16 ml., p=0.032), higher rates of pregnancy-induced hypertension (22.00% vs 2.00%, p<.001), and preterm birth (42.00% vs 8.00%, p<.001). Neonatal outcomes showed lower birth weight (2,689.61±540.12 vs 3,091.04±460.82 g, p<.001), smaller head circumference (32.28±1.66 vs 33.62±2.33 cm, p<.001) and longer neonatal hospital stay (11.01±18.76 vs 3.49±2.14 days, p<0.001). Multivariable logistic regression showed that preterm birth (adjusted OR 0.140; 95% CI 0.055–0.357, p<0.001) and PIH (adjusted OR 0.044; 95% CI 0.009–0.230, p<0.001) remained significantly associated after adjusting for confounders.

Conclusions: Amphetamine use in singleton pregnancies was significantly affected by adverse maternal and neonatal outcomes, including pregnancy-induced hypertension and preterm birth. Routine drug screening policies and multidisciplinary care approaches for pregnant women should be developed.

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