Incidence of Ischemic Stroke or Acute Thromboembolism Treated with Intravenous Fibrinolytic Drugs in Phon Thong Hospital, Roi Et Province

Abstract

Background: Acute ischemic stroke is a neurological emergency that requires correct and prompt treatment. Otherwise, there will be a high death rate. Close monitoring of therapy and clinical changes in this group of patients is key to evaluating treatment results and preventing complications that may occur after treatment.

Objective: To study the incidence of stroke and find key risk factors of stroke occurrence in Phon Thong Hospital, Roi Et Province. Effects of stroke treatment after treatment with thrombolytic drugs and evaluating the incidence of complications after stroke treatment with thrombolytic drugs.

Method of Study: Retrospective descriptive study of electronic medical records of patients diagnosed with acute ischemic stroke. Who received blood clot-dissolving drugs and was admitted to the stroke ward at Phon Thong Hospital, Roi Et Province, from October 2020 to September 2023.

Results: From a total of 128 patients studied, the most of patients were 71 (55.47%) female and 57 (45.53%) male. The patients had an average age of 67.8±10.9 years after treatment. Intravenous blood thinners: 100 patients (78.13%) had improved or stable symptoms. The mean time from symptom onset to receiving thrombolytic drugs was 158.5±42.2 minutes, the mean time from hospital admission to receiving intravenous thrombolytic drugs was 71.8±28.4 minutes, and the mean time from the time from symptom onset to arrival at the hospital was 89±41.2 minutes. The average NIHSS value time of admission to the emergency room was 11.1±5.8. The 23 patients (17.97%) developed brain hemorrhage after treatment with blood thinners. This cerebral hemorrhage has a prediction statistic of significantly worse treatment outcome (OR=144.66, 95% CI: 13.19-1585.60, p-value < 0.0001). Risk factors that have a statistically significant prediction of worse treatment outcomes. Including age > 65 years (OR=0.12, 95% CI: 0.02-0.58, p-value=0.008*).  Hypertension (OR=0.19, 95% CI: 0.04-0.91, p-value=0.03*). Patients with AF (OR=0.22, 95% CI: 0.08-0.94, p-value=0.04*) and Intracerebral hemorrhage had a statistically significant association with worse outcomes.

Conclusion: Treatment of acute stroke with intravenous thrombolytic drugs is highly effective in rehabilitating symptoms and reducing disability. Control risk factors such as age, and blood pressure. Preventing brain hemorrhage after treatment can effectively reduce the risk of stroke and improve treatment outcomes.