The study of factors associated to Early Onset Neonatal Sepsis In Neonates in Yasothon hospital
Keywords:
Early Onset Neonatal Sepsis (EONS), Suspected and Confirmed Early-Onset Neonatal SepsisAbstract
Background: Neonatal sepsis is one of the leading causes of neonatal mortality worldwide. In Thailand, it is found that 8.4% of neonatal sepsis newborns admitted to neonatal intensive care units.
Objective: To study the factors associated with suspected and confirmed early-onset neonatal sepsis and short-term outcomes in infants with a gestational age of 34 weeks or more admitted to the neonatal unit at Yasothon Hospital.
Methods: A retrospective study was conducted using medical records of newborns diagnosed with early-onset neonatal sepsis from January 1st, 2023, to December 31st, 2024. Factors associated with suspected and confirmed early-onset neonatal sepsis group were analyzed.
Results: A total of 291 infants were included in the study. The majority were male (53.9%), full-term infants accounted for 78.7%, and preterm infants accounted for 21.3%. The most common clinical manifestations of early-onset neonatal sepsis were respiratory symptoms (44.1%), jaundice (34.3%), and fever (22.9%). The average hospital stay was 11.3 days, and there were 2 deaths (0.6%).
When analyzing the subgroup of 76 infants who met the criteria for suspected and confirmed early-onset neonatal sepsis, seven factors were found to be significantly associated with the condition: 1.) Gestational age (p=0.002), particularly in infants born at 29-34 weeks. 2.) Maternal age (p=0.032), particularly mothers younger than 19 years. 3.) Preterm labor before 37 weeks of gestation (p=0.007). 4.) Inappropriate maternal antibiotic use (p=0.017) 5.) Neonatal fever (p<0.01) 6.) Respiratory symptoms in the infant (p<0.01) and 7.) Abdominal distension or feeding intolerance (p=0.011)
Conclusion: The identification of these seven factors associated with suspected and confirmed early-onset neonatal sepsis highlights the importance of developing a screening process starting before birth in the delivery room, as well as postnatal monitoring in the postpartum ward.
Keywords: Early-onset neonatal sepsis (EONS), Suspected and confirmed early-onset neonatal sepsis
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