ปัจจัยที่มีความสัมพันธ์ต่อการพบความผิดปกติในเอกซเรย์คอมพิวเตอร์สมองในผู้ป่วยบาดเจ็บที่ศีรษะ ไม่รุนแรง: การศึกษาเปรียบเทียบย้อนหลังในโรงพยาบาลสมเด็จพระยุพราชกระนวน
Factors Associated with Abnormal Findings on Brain Computed Tomography in Patients with Mild Traumatic Brain Injury: A Retrospective Comparative Study at Kranuan Crown Prince Hospital
Keywords:
Mild traumatic brain injury; CT Brain; associated factors; community hospital; head injury, การบาดเจ็บที่ศีรษะไม่รุนแรง, เอกซเรย์คอมพิวเตอร์สมอง, ปัจจัยที่มีความสัมพันธ์, โรงพยาบาลชุมชน, การบาดเจ็บที่ศีรษะ, Mild traumatic brain injury, CT Brain, associated factors, community hospital, head injuryAbstract
Background: Mild traumatic brain injury (MTBI) is a common emergency condition encountered in community hospital emergency departments. Computed tomography of the brain (CT Brain) plays a crucial role in detecting intracranial hemorrhage that requires urgent management. However, performing CT scans without appropriate screening criteria may lead to unnecessary healthcare costs and avoidable radiation exposure.
Objective: To determine the prevalence and types of abnormalities detected on CT Brain and to identify factors associated with these abnormalities in patients with mild traumatic brain injury (MTBI) at Kranuan Crown Prince Hospital, Khon Kaen Province.
Methods: This retrospective analytical study was conducted using medical records of patients diagnosed with mild traumatic brain injury (Glasgow Coma Scale score 13–15), aged 15 years and older, who underwent CT Brain at Kranuan Crown Prince Hospital between January 1, 2023, and December 31, 2025. Independent variables included sex, age, mechanism of injury, clinical signs and symptoms, underlying diseases, and medication history. Data were analyzed using descriptive statistics, Chi-square test, Fisher’s exact test, and multivariate logistic regression. Statistical significance was set at p < 0.05.
Results: A total of 440 patients met the inclusion criteria, of whom 58.6% were male. CT Brain abnormalities were detected in 81 patients, accounting for 18.4% (95% CI: 14.8–22.0). The most common abnormality was subarachnoid hemorrhage (65.4%), followed by subdural hemorrhage (60.5%), intracerebral hemorrhage (35.8%), and epidural hemorrhage (27.2%). Multiple types of abnormalities were observed in 56.8% of cases.
Multivariate analysis identified motorcycle-related accidents (Adjusted OR = 2.15, 95% CI: 1.27–3.65, p = 0.004) and age < 60 years (Adjusted OR = 1.78, 95% CI: 1.06–3.00, p = 0.030) as independent factors significantly associated with CT Brain abnormalities.
Regarding clinical outcomes, no patients required neurosurgical intervention, referral, or experienced mortality. At one-month follow-up, 99.5% of patients had a Glasgow Outcome Scale score of 5.
Conclusion: Motorcycle-related accidents and age below 60 years were independent risk factors associated with CT Brain abnormalities in patients with MTBI in a community hospital setting. The identified risk factors may serve as a basis for developing appropriate clinical decision-making guidelines for CT Brain utilization in MTBI patients in community hospitals, thereby reducing unnecessary imaging and minimizing radiation exposure without clear indications.
Keywords: Mild traumatic brain injury; CT Brain; associated factors; community hospital; head injury
References
เอกสารอ้างอิง
Zhong H, Feng Y, Shen J, Rao T, Dai H, Zhong W, et al. Global Burden of Traumatic Brain Injury in 204 Countries and Territories From 1990 to 2021. Am J Prev Med 2025; 68(4): 754-63. doi: 10.1016/j.amepre.2025.01.001. PubMed PMID: 39793770.
Maas AIR, Menon DK, Manley GT, Abrams M, Åkerlund C, Andelic N, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol 2022; 21(11): 1004-60. doi: 10.1016/S1474-4422(22)00309-X. PubMed PMID: 36183712.
World Health Organization. Global status report on road safety 2023 [Internet]. 2023 [Cited 2025 Apr 30]. Available from: https://www.who.int/teams/social-determinants-of-health/safety-and-mobility/global-status-report-on-road-safety-2023
World Health Organization South-East Asia Regional Office. WHO South-East Asia Regional status report on road safety: Towards safer and sustainable mobility [Internet]. 2024 [Cited 2025 Apr 30]. Available from: https://www.who.int/publications/i/item/9789290211730
World Health Organization Thailand. Road safety [Internet]. 2023 [Cited 2025 Apr 30]. Available from: https://www.who.int/thailand/our-work/road-safety
Kungsukun N, Kaeoaudom S, Wattanapisit A. The seven dangerous days: Thailand's biannual road traffic accident surges linked to inequality. Lancet Reg Health Southeast Asia 2024; 32: 100513. doi: 10.1016/j.lansea.2024.100513. PubMed PMID: 39698511.
Eastern Association for the Surgery of Trauma. Traumatic Brain Injury, Mild - Practice Management Guideline [Internet]. 2025 [Cited 2025 Apr 30]. Available from: https://www.east.org/education-resources/practice-management-guidelines/details/traumatic-brain-injury-mild
Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR, et al. Pathological computed tomography features associated with adverse outcomes after mild traumatic brain injury: a TRACK-TBI study with external validation in CENTER-TBI. JAMA Neurol 2021; 78(9): 1137-48. doi: 10.1001/jamaneurol.2021.2120. PubMed PMID: 34279565.
Richter S, Winzeck S, Correia MM, Czeiter E, Whitehouse D, Kornaropoulos EN, et al. Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI). EClinicalMedicine 2024; 75: 102751. doi: 10.1016/j.eclinm.2024.102751. PubMed PMID: 39720677.
Ganti L, Vijayashanker A, Bhamidipati D, Kota S. Peri-injury symptomatology as predictors of brain computed tomography (CT) scan abnormalities in mild traumatic brain injury. Int J Emerg Med 2024; 17(1):168. doi: 10.1186/s12245-024-00754-7.
ภาณุ ธีรตกุลพิศาล, ผาติ อังคสิทธิ์, ปาริชาติ ตันมิตร, ธนากร วรรณกุล, ไชยยุทธ ธนไพศาล. ปัจจัยที่ส่งผลต่อความผิดปกติจากเอกซเรย์คอมพิวเตอร์ในกรณีสมองบาดเจ็บไม่รุนแรงที่มีความเสี่ยงสูง. ศรีนครินทร์เวชสาร มีนาคม-เมษายน 2564; 36(2): 131-6.
Lagares A, Castaño-Leon AM, Richard M, Tsitsopoulos PP, Morales J, Mihai P, et al. Variability in the indication of brain CT scan after mild traumatic brain injury: a transnational survey. Eur J Trauma Emerg Surg 2023; 49(3): 1189-98. doi: 10.1007/s00068-022-01902-5. PubMed PMID: 35178583.
Yuksen C, Sittichanbuncha Y, Patumanond J, Muengtaweepongsa S, Sawanyawisuth K. Clinical predictive score of intracranial hemorrhage in mild traumatic brain injury. Ther Clin Risk Manag 2018; 14: 213-8. doi: 10.2147/TCRM.S147079. PubMed PMID: 29440905.
Yuksen C, Ladarat P, Jenpanitpong C, Nuwannawa P, Yuranon Y, Wongrujirakit S, et al. Validity of mild TBI risk score to predict intracranial hemorrhage in cases of mild traumatic brain injury in Thailand. BMJ Open 2020; 10(5): e032364. doi: 10.1136/bmjopen-2019-032364.
Yang LJ, Lassarén P, Londi F, Palazzo L, Fletcher-Sandersjöö A, Ängeby K, et al. Risk factors for traumatic intracranial hemorrhage in mild traumatic brain injury patients at the emergency department: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med 2024; 32(1): 91. doi: 10.1186/s13049-024-01262-6. PubMed PMID: 39289729.
Aramvanitch K, Yuksen C, Jenpanitpong C, Nuanprom P, Phootothum Y, Phontabtim M, et al. Validity of mild TBI risk score to predict intracranial hemorrhage in cases of mild traumatic brain injury in Thailand. Trauma Surg Acute Care Open 2020; 5(1): e000453. doi: 10.1136/tsaco-2020-000453. PubMed PMID: 32377569.
Saran M, Arab-Zozani M, Behzadifar M, Gholami M, Azari S, Bragazzi NL, et al. Overuse of computed tomography for mild head injury: a systematic review and meta-analysis. PLoS One 2024; 19(1): e0293558. doi: 10.1371/journal.pone.0293558. PubMed PMID: 38206917.
Vasista S, Saint-Fleur J, Kapoor N, Ganti L. Peri-injury symptomatology as predictors of brain computed tomography (CT) scan abnormalities in mild traumatic brain injury (mTBI). Int J Emerg Med 2024; 17(1): 171. doi: 10.1186/s12245-024-00754-7. PubMed PMID: 39501137.
Griswold DP, Fernandez L, Rubiano AM. Traumatic subarachnoid hemorrhage: a scoping review. J Neurotrauma 2022; 39(1–2): 35–48. doi: 10.1089/neu.2021.0007. PubMed PMID: 33637023.
Banson M, Ametefe MK, Darko K, Dakubo JCB, Iddrisu M, Dakurah T. Comparative analysis of traumatic brain injury severity in motorcycle and car accident victims treated at Korle-Bu Teaching Hospital. J West Afr Coll Surg 2025; 15(1): 75–82. doi: 10.4103/jwas.jwas_188_23. PubMed PMID: 39735816.
Ahmad S, Rehman L, Afzal A, Javeed F. Outcome of head injury in motorbike riders. Pak J Med Sci 2023; 39(2): 390–94. doi: 10.12669/pjms.39.2.6371. PubMed PMID: 36950418.
Stiell IG, Wells GA, Vandemheen K, Clement C, Lesiuk H, Laupacis A, et al. The Canadian CT Head Rule for patients with minor head injury. Lancet 2001; 357(9266): 1391-6. doi: 10.1016/s0140-6736(00)04561-x. PubMed PMID: 11356436.
Nugraha EW, Tumboimbela MJ, Ngantung DJ, Wariki WMV, Tumewah R, Warouw F. Indicators of abnormal CT scan findings in clinically mild traumatic brain injury patients. Neurology Asia 2024; 29(1): 207–13. doi: 10.54029/2024wwh.
Chairattanawan P, Angkoontassaneeyarat C, Yuksen C, Jenpanitpong C, Phontabtim M, Laksanamapune T. Early discharge versus 6-hour observation in mild traumatic brain injury with normal brain CT scan: a comparative pilot study of outcomes. Arch Acad Emerg Med 2024; 12(1): e50. doi: 10.22037/aaem.v12i1.2245. PubMed PMID: 38962367.
Santing JAL, Van Gent M, Van Den Brand CL, Van Der Naalt J, Jellema K. Hospital admission of older patients with mild traumatic brain injury and traumatic intracranial hemorrhage: is it always necessary? Eur J Trauma Emerg Surg 2025; 51(1): 8. doi: 10.1007/s00068-024-02671-z. PubMed PMID: 39799536.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 YASOTHON MEDICAL JOURNAL

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของยโสธรเวชสาร
