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Factors Affecting the Prevention of Repeated Fractures in the Elderly after Hip Bone Treatment: Last Data Analysis in Yasothon Hospital

Authors

  • Pichetpong Ganyakam Yasothon Hospital, Yasothon Province

Keywords:

Subsequent fractures, Hip fractures, Secondary prevention, Anti-osteoporotic medications, Elderly patients

Abstract

Background: Hip fractures in the elderly are a major public health problem. Patients who have previously had a hip fracture have a 2.5-3.0 times higher risk of repeat fracture, with a significant impact on mortality and quality of life, despite evidence that secondary prevention measures are effective. But hospitals in Thailand still face a significant care gap, especially in the northeastern region. Yasothon Hospital found that only 22.7% of patients received anti-osteoporosis medication after a hip fracture. This is lower than the national average of 27.4%, along with an important limitation: there is no DEXA machine for checking bone density. The current patient tracking system lacks in-depth studies on which preventive measures are most effective and can actually be implemented in secondary general hospitals. Which has limited resources and must accommodate a large number of elderly people from both urban and remote rural areas.

Objective: To investigate factors affecting the prevention of subsequent fractures in elderly patients following hip fracture treatment at Yasothon Hospital.

Methods: Retrospective data analysis study, by reviewing medical records of elderly patients (age ≥ 60 years) receiving treatment for hip fractures. Between January 2019 and December 2022, continuous treatment follow-up data were available for 24 months (until the end of follow-up on December 31, 2024), and a total of 180 patients were analyzed. Data were analyzed using descriptive statistics. Univariate and multivariate analysis with logistic regression and person-time analysis.

Results: The incidence of subsequent fractures was 15.6% (28 of 180 patients) during the 24-month follow-up period. Independent risk factors included history of falls (Adjusted OR = 3.21, 95% CI: 1.18-8.73, p = 0.022), age ≥ 75 years (Adjusted OR = 2.89, 95% CI: 1.12-7.45, p = 0.028), and previous fracture history (Adjusted OR = 2.67, 95% CI: 1.05-6.78, p = 0.039). Effective preventive measures included good medication adherence (Adjusted OR = 0.24, 95% CI: 0.07-0.82, p = 0.022) reducing risk by 76%, anti-osteoporotic medication use (Adjusted OR = 0.28, 95% CI: 0.09-0.84, p = 0.023) reducing risk by 72%, participation in fall prevention programs (Adjusted OR = 0.31, 95% CI: 0.10-0.96, p = 0.041) reducing risk by 69%, and regular follow-up visits (Adjusted OR = 0.35, 95% CI: 0.14-0.89, p = 0.027) reducing risk by 65%. Person-time analysis revealed an overall incidence density of 7.8 per 100 person-years. Patients receiving anti-osteoporotic medications had a subsequent fracture rate of 6.3% compared to 18.9% in those not receiving treatment (Risk Difference = -12.6%, RR = 0.33, p = 0.042). However, significant care gaps were identified, with only 26.7% of patients receiving anti-osteoporotic medications.

 

Conclusion: Preventing recurrent fractures can be effectively achieved through consistent use of anti-osteoporosis medication, enhanced patient compliance, continuous follow-up care, and fall prevention programs. The development of comprehensive care systems tailored to community hospital contexts is crucial for addressing care gaps and enhancing outcomes for this patient population.

Author Biography

Pichetpong Ganyakam, Yasothon Hospital, Yasothon Province

M.D., Thai Board of Orthopaedics

References

Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006; 17(12): 1726-33. doi: 10.1007/s00198-006-0172-4. PubMed PMID: 16983459.

Nazrun AS, Tzar MN, Mokhtar SA, Mohamed IN. A systematic review of the outcome of osteoporotic fracture patients after hospital discharge: morbidity, subsequent fractures, and mortality. Ther Clin Risk Manag 2014; 10: 937-48. doi: 10.2147/TCRM.S72456. PubMed PMID: 25429224.

Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int 1992; 2(6): 285-9. doi: 10.1007/BF01623184. PubMed PMID: 1421796.

Song M, Wang Y, Jiang Y, Pi H, Lyu H, Gao Y. Risk factors for subsequent fractures in hip fracture patients: a nested case-control study. J Orthop Surg Res 2024; 19(1): 348. doi: 10.1186/s13018-024-04833-6. PubMed PMID: 38867268.

Wang Y, Shen W, Jiang J, Wang L, Xia Q, Shao Y, et al. Risk Factors for Recurrent Hip Fractures Following Surgical Treatment of Primary Osteoporotic Hip Fractures in Chinese Older Adults. Diseases 2025; 13(11): 351. doi: 10.3390/diseases13110351. PubMed PMID: 41294891.

Liow MHL, Ganesan G, Chen JDY, Koh JSB, Howe TS, Yong EL, et al. Excess mortality after hip fracture: fracture or pre-fall comorbidity. Osteoporos Int 2021; 32(12): 2485-92. doi: 10.1007/s00198-021-06023-0. PubMed PMID: 34129060.

มูลนิธิสถาบันวิจัยและพัฒนาผู้สูงอายุไทย. สถานการณ์ผู้สูงอายุไทย พ.ศ. 2564. กรุงเทพฯ: มูลนิธิสถาบันวิจัยและพัฒนาผู้สูงอายุไทย; 2565.

กองยุทธศาสตร์และแผนงาน กระทรวงสาธารณสุข. รายงานข้อมูลทรัพยากรสาธารณสุข ประจำปี 2565. นนทบุรี: กระทรวงสาธารณสุข; 2566.

Chotiyarnwong P, Harvey NC, Johansson H, Liu E, Lorentzen M, Kanis JA, et al. Temporal changes in access to FRAX® in Thailand between 2010 and 2018. Arch Osteoporos 2019; 14(1): 66. doi: 10.1007/s11657-019-0613-2. PubMed PMID: 31227921.

Vanichkachorn S, Suriyawongpaisal P, Keereevijit A, Songpatanasilp T. One-year mortality and quality of life outcomes in Thai elderly after hip fracture: a prospective cohort study. Arch Osteoporos 2023; 18(1): 32.

คณะเศรษฐศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย. รายงานการศึกษาต้นทุนทางเศรษฐศาสตร์ของการดูแลรักษาผู้ป่วยกระดูกสะโพกหักในประเทศไทย. กรุงเทพฯ: จุฬาลงกรณ์มหาวิทยาลัย; 2564.

สำนักงานหลักประกันสุขภาพแห่งชาติ. รายงานการเบิกจ่ายค่ารักษาพยาบาลผู้ป่วยกระดูกหัก ปีงบประมาณ 2565. นนทบุรี: สำนักงานหลักประกันสุขภาพแห่งชาติ; 2566.

Wattanasit P, Indaratna K, Sakulbumrungsil R, Ingsathit A. Economic and psychosocial burden of caregivers of hip fracture patients in Thailand. Value Health Reg Issues 2023; 35: 102-10.

Rojnawee S, Mamkong A, Stitkitti N, Kuanprasert S. Incidence and risk factors of subsequent fractures after initial hip fracture among Thai elderly: a multicenter prospective study. J Med Assoc Thai 2023; 106(7): 652-9.

Pongchaiyakul C, Leerapun T, Wongtriratanachai P, Rojnawee S, Chotiyarnwong P. Treatment gaps in patients with osteoporotic fracture in Thailand. Osteoporos Sarcopenia 2022; 8(3): 121-6.

Jitapunkul S, Chaiard J, Thamlikitkul V, Udol K, Tantiphiphatthana T. Medication adherence to anti-osteoporotic drugs and associated factors among Thai elderly patients. Aging Clin Exp Res 2023; 35(6): 1125-33.

Jensen MH, Vestergaard P, Tofteng CL, Storgaard M, Rejnmark L. Bisphosphonate treatment after a fracture: adherence and effectiveness on future fracture risk. Osteoporos Int 2022; 33(1): 165-73.

Thanapluetiwong S, Chewcharat A, Takkavatakarn K, Praditpornsilpa K, Eiam-Ong S, Susantitaphong P. Calcium and vitamin D supplementation for prevention of fracture in older adults: an updated meta-analysis. Nutrients 2022; 14(9): 1885.

Sherrington C, Fairhall N, Kwok W, Wallbank G, Tiedemann A, Michaleff ZA, et al. Evidence on physical activity and falls prevention for people aged 65+ years: systematic review to inform the WHO guidelines on physical activity and sedentary behaviour. Int J Behav Nutr Phys Act 2020; 17(1): 144. doi: 10.1186/s12966-020-01041-3. PubMed PMID: 33239019.

Wu CH, Tu ST, Chang YF, Chan DC, Chien JT, Lin CH, et al. Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: a systematic literature review and meta-analysis. Bone 2018; 111: 92-100. doi: 10.1016/j.bone.2018.03.018. PubMed PMID: 29555309.

Curtis JR, Delzell E, Chen L, Black D, Ensrud K, Judd S, et al. The relationship between bisphosphonate adherence and fracture: is it the behavior or the medication? Results from the placebo arm of the fracture intervention trial. J Bone Miner Res 2011; 26(4): 683-8. doi: 10.1002/jbmr.274. PubMed PMID: 20939064.

Balasubramanian A, Zhang J, Chen L, Wenkert D, Daigle SG, Grauer A, et al. Risk of subsequent fracture after prior fracture among older women. Osteoporos Int 2019; 30(1): 79-92. doi: 10.1007/s00198-018-4732-1. PubMed PMID: 30456571.

Center JR, Bliuc D, Nguyen TV, Eisman JA. Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 2007; 297(4): 387-94. doi: 10.1001/jama.297.4.387. PubMed PMID: 17244835.

Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, et al. Benefits and risks of bisphosphonate therapy for osteoporosis. J Clin Endocrinol Metab 2012; 97(7): 2272-82. doi: 10.1210/jc.2012-1027. PubMed PMID: 22523337.

Lyles KW, Colón-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 2007; 357(18): 1799-809. doi: 10.1056/NEJMoa074941. PubMed PMID: 17878149.

Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2012; (9): CD007146. doi: 10.1002/14651858.CD007146.pub3. PubMed PMID: 22972103.

Nakayama A, Major G, Holliday E, Attia J, Bogduk N. Evidence of effectiveness of a fracture liaison service to reduce the re-fracture rate. Osteoporos Int 2016; 27(3): 873-9. doi: 10.1007/s00198-015-3443-0. PubMed PMID: 26650377.

Ganda K, Puech M, Chen JS, Speerin R, Bleasel J, Center JR, et al. Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis. Osteoporos Int 2013; 24(2): 393-406. doi: 10.1007/s00198-012-2090-y. PubMed PMID: 22829395.

Alsadhan I, Alyusuf EY, Shaltoot O, AlRuwashid S, Alhamad M, Ekhzaimy A, et al. Adoption of telemedicine care for osteoporotic patients during the COVID-19 pandemic: experience from a tertiary care center in Saudi Arabia. Arch Osteoporos 2022; 18(1): 16. doi: 10.1007/s11657-022-01207-5. PubMed PMID: 36576607.

Kanis JA, Harvey NC, Johansson H, Odén A, Leslie WD, McCloskey EV. FRAX update. J Clin Densitom 2017; 20(3): 360-7. doi: 10.1016/j.jocd.2017.06.022. PubMed PMID: 28732576.

Palcu P, Munce S, Jaglal SB, Allin S, Chishtie JA, Silverstein A, et al. Understanding patient experiences and challenges to osteoporosis care delivered virtually by telemedicine: a mixed methods study. Osteoporos Int 2020; 31(2): 351-61. doi: 10.1007/s00198-019-05182-5. PubMed PMID: 31760454.

Gupta A, Maslen C, Vindlacheruvu M, Abel RL, Bhattacharya P, Bromiley PA, et al. Digital health interventions for osteoporosis and post-fragility fracture care. Ther Adv Musculoskelet Dis 2022; 14: 1759720X221083523. doi: 10.1177/1759720X221083523. PubMed PMID: 35368375.

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2025-12-22

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How to Cite

Ganyakam, P. (2025). Factors Affecting the Prevention of Repeated Fractures in the Elderly after Hip Bone Treatment: Last Data Analysis in Yasothon Hospital. YASOTHON MEDICAL JOURNAL, 27(3), 2733883. retrieved from https://he04.tci-thaijo.org/index.php/hciyasohos/article/view/3883